68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33147593" target="_blank" >RIV/61989592:15110/14:33147593 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11307-013-0654-7" target="_blank" >http://dx.doi.org/10.1007/s11307-013-0654-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11307-013-0654-7" target="_blank" >10.1007/s11307-013-0654-7</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms
Popis výsledku v původním jazyce
Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and humanlung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro
Název v anglickém jazyce
68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms
Popis výsledku anglicky
Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and humanlung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
MOLECULAR IMAGING AND BIOLOGY
ISSN
1536-1632
e-ISSN
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Svazek periodika
16
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
102-108
Kód UT WoS článku
000329793200013
EID výsledku v databázi Scopus
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