Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33148990" target="_blank" >RIV/61989592:15110/14:33148990 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0165178114002261/1-s2.0-S0165178114002261-main.pdf?_tid=b1112514-7c79-11e4-93cf-00000aab0f6c&acdnat=1417782463_6680883a271d3ff12167660d94a0ec1b" target="_blank" >http://ac.els-cdn.com/S0165178114002261/1-s2.0-S0165178114002261-main.pdf?_tid=b1112514-7c79-11e4-93cf-00000aab0f6c&acdnat=1417782463_6680883a271d3ff12167660d94a0ec1b</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.psychres.2014.03.020" target="_blank" >10.1016/j.psychres.2014.03.020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene

Popis výsledku v původním jazyce

Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokinestogether with their receptors associate with this disorder. Interleukin-2 receptor gamma (IL-2RG) represents an important signaling component of many interleukin receptors and so far, no data on the functional state of this receptor in schizophrenia havebeen reported. The aim of this study was to investigate mRNA expression of the IL2RG gene (IL2RG) in schizophrenia patients in comparison with healthy subjects (controls). Total RNA was isolated from peripheral blood of 66 schizophrenia patients and 99healthy subjects of Armenian population. The mRNA expression was determined by quantitative real-time polymerase chain reaction (RT-PCR) using PSMB2 as housekeeping gene. IL2RG mRNA expression was upregulated in peripheral blood of patien

Název v anglickém jazyce

Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene

Popis výsledku anglicky

Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokinestogether with their receptors associate with this disorder. Interleukin-2 receptor gamma (IL-2RG) represents an important signaling component of many interleukin receptors and so far, no data on the functional state of this receptor in schizophrenia havebeen reported. The aim of this study was to investigate mRNA expression of the IL2RG gene (IL2RG) in schizophrenia patients in comparison with healthy subjects (controls). Total RNA was isolated from peripheral blood of 66 schizophrenia patients and 99healthy subjects of Armenian population. The mRNA expression was determined by quantitative real-time polymerase chain reaction (RT-PCR) using PSMB2 as housekeeping gene. IL2RG mRNA expression was upregulated in peripheral blood of patien

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatry Research

ISSN

0165-1781

e-ISSN

—

Svazek periodika

217

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

158-162

Kód UT WoS článku

000336878400006

EID výsledku v databázi Scopus

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