Chemical Properties and Biological Activities of Cyclopentenediones: A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33149191" target="_blank" >RIV/61989592:15110/14:33149191 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/14:10282273

Výsledek na webu

<a href="http://www.eurekaselect.com/120771/article" target="_blank" >http://www.eurekaselect.com/120771/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1389557514666140306130207" target="_blank" >10.2174/1389557514666140306130207</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chemical Properties and Biological Activities of Cyclopentenediones: A Review

Popis výsledku v původním jazyce

Cyclopentenediones (CPDs) are secondary metabolites of higher plants, fungi, algae, cyanobacteria and bacteria. A common denominator of CPDs is the cyclopent-4-ene 1,3-dione skeleton (1), which is modified by several functional groups. The heterogeneityof these substitutions is reflected in around one hundred CPDs reported to date. Most of the derivatives were isolated primarily from plant sources. Synthetic analogues were then prepared with new biological activities and more interesting pharmacological potential. Antifungal substances called coruscanones (2, 3) are the most studied of the CPDs. Other intensely investigated CPDs include lucidone (4), linderone (5), asterredione (6), involutone (7), nostotrebin 6 (8), TX-1123 (9), G2201-C (10), madindolines (11, 12) and many others. In addition to antibacterial and antifungal effects, a broad spectrum of biological activities for CPDs has been reported in the past two decades, especially anti-inflammatory, cytostatic and specific enzym

Název v anglickém jazyce

Chemical Properties and Biological Activities of Cyclopentenediones: A Review

Popis výsledku anglicky

Cyclopentenediones (CPDs) are secondary metabolites of higher plants, fungi, algae, cyanobacteria and bacteria. A common denominator of CPDs is the cyclopent-4-ene 1,3-dione skeleton (1), which is modified by several functional groups. The heterogeneityof these substitutions is reflected in around one hundred CPDs reported to date. Most of the derivatives were isolated primarily from plant sources. Synthetic analogues were then prepared with new biological activities and more interesting pharmacological potential. Antifungal substances called coruscanones (2, 3) are the most studied of the CPDs. Other intensely investigated CPDs include lucidone (4), linderone (5), asterredione (6), involutone (7), nostotrebin 6 (8), TX-1123 (9), G2201-C (10), madindolines (11, 12) and many others. In addition to antibacterial and antifungal effects, a broad spectrum of biological activities for CPDs has been reported in the past two decades, especially anti-inflammatory, cytostatic and specific enzym

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP207%2F10%2F2048" target="_blank" >GAP207/10/2048: Chirální chinazolinové alkaloidy: Potenciální prototypy nových antiastmatik a organokatalyzátorů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mini-Reviews in Medicinal Chemistry

ISSN

1389-5575

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

322-331

Kód UT WoS článku

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EID výsledku v databázi Scopus

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