Intestinal permeability in patients with metastatic colon cancer treated with patupilone

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150508" target="_blank" >RIV/61989592:15110/14:33150508 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10282938 RIV/00179906:_____/14:10282938

Výsledek na webu

<a href="http://dx.doi.org/10.1515/cclm-2014-0096" target="_blank" >http://dx.doi.org/10.1515/cclm-2014-0096</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2014-0096" target="_blank" >10.1515/cclm-2014-0096</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Intestinal permeability in patients with metastatic colon cancer treated with patupilone

Popis výsledku v původním jazyce

Background: Only a limited number of cytotoxic drugs have shown activity in metastatic colorectal carcinoma. Patupilone is a novel agent with promising activity in this common cancer. Diarrhea represents the dose-limiting toxicity of patupilone. Measurement of intestinal permeability is one of the potential methods of non-invasive laboratory assessment of gastrointestinal toxicity. Methods: We have assessed intestinal permeability by measuring absorption of lactulose, mannitol and xylose in 27 previously treated patients with metastatic colorectal cancer enrolled in a phase I trial of patupilone. Results: Lactulose/mannitol and lactulose/xylose ratios increased after the treatment. Significantly higher lactulose/ mannitol ratio was observed in patientswho had severe diarrhea. Moreover, patients who subsequently had an adverse event of grade 3 or higher had significantly higher baseline lactulose/mannitol or lactulose/xylose ratios. Conclusions: Measurement of intestinal permeability u

Název v anglickém jazyce

Intestinal permeability in patients with metastatic colon cancer treated with patupilone

Popis výsledku anglicky

Background: Only a limited number of cytotoxic drugs have shown activity in metastatic colorectal carcinoma. Patupilone is a novel agent with promising activity in this common cancer. Diarrhea represents the dose-limiting toxicity of patupilone. Measurement of intestinal permeability is one of the potential methods of non-invasive laboratory assessment of gastrointestinal toxicity. Methods: We have assessed intestinal permeability by measuring absorption of lactulose, mannitol and xylose in 27 previously treated patients with metastatic colorectal cancer enrolled in a phase I trial of patupilone. Results: Lactulose/mannitol and lactulose/xylose ratios increased after the treatment. Significantly higher lactulose/ mannitol ratio was observed in patientswho had severe diarrhea. Moreover, patients who subsequently had an adverse event of grade 3 or higher had significantly higher baseline lactulose/mannitol or lactulose/xylose ratios. Conclusions: Measurement of intestinal permeability u

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

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Svazek periodika

52

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

1649-1655

Kód UT WoS článku

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EID výsledku v databázi Scopus

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