Determination of adipokine expression in the peripheral blood leukocytes of young patients with myocardial infarction
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33151444" target="_blank" >RIV/61989592:15110/14:33151444 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00098892:_____/14:#0000780
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Determination of adipokine expression in the peripheral blood leukocytes of young patients with myocardial infarction
Popis výsledku v původním jazyce
Objectives: Little is known about the effect of adipokines in the pathogenesis of the acute myocardial infarction (AMI) in young patients. The aim of this pilot study was to evaluate whether it is possible to detect mRNA expressions of selected adipokines in the peripheral blood leukocytes of young patients with myocardial infarction. Methods: We prospectively examined 42 patients who had an acute myocardial infarction (AMI) at a young age (men 18-45 years of age and women 18-55 years of age) and control groups of 31 patients with metabolic syndrome and 15 healthy individuals. RNA was isolated from their peripheral blood leukocytes and transcribed into cDNA (transcription kit iSCRIPT). Subsequently, the expression of the following genes were analysed (LC 480II, BioVendor kits): Adipocyte Fatty Acid Binding protein (AFABP, FABP4), Leptin and Adiponectin receptor 2 (ADN-R2). Beta-2-microglobulin was examined as a housekeeping gene. Results: In the group of patients after AMI the expressi
Název v anglickém jazyce
Determination of adipokine expression in the peripheral blood leukocytes of young patients with myocardial infarction
Popis výsledku anglicky
Objectives: Little is known about the effect of adipokines in the pathogenesis of the acute myocardial infarction (AMI) in young patients. The aim of this pilot study was to evaluate whether it is possible to detect mRNA expressions of selected adipokines in the peripheral blood leukocytes of young patients with myocardial infarction. Methods: We prospectively examined 42 patients who had an acute myocardial infarction (AMI) at a young age (men 18-45 years of age and women 18-55 years of age) and control groups of 31 patients with metabolic syndrome and 15 healthy individuals. RNA was isolated from their peripheral blood leukocytes and transcribed into cDNA (transcription kit iSCRIPT). Subsequently, the expression of the following genes were analysed (LC 480II, BioVendor kits): Adipocyte Fatty Acid Binding protein (AFABP, FABP4), Leptin and Adiponectin receptor 2 (ADN-R2). Beta-2-microglobulin was examined as a housekeeping gene. Results: In the group of patients after AMI the expressi
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Experimental and Clinical Cardiology
ISSN
1205-6626
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
13
Strana od-do
1182-1194
Kód UT WoS článku
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EID výsledku v databázi Scopus
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