Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33150889" target="_blank" >RIV/61989592:15110/15:33150889 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/15:#0000905

Výsledek na webu

<a href="http://dx.doi.org/10.1111/jdv.12468" target="_blank" >http://dx.doi.org/10.1111/jdv.12468</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jdv.12468" target="_blank" >10.1111/jdv.12468</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer

Popis výsledku v původním jazyce

Background Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen-dependent disorders. Objective To investigate the relationships between male androgenetic alopecia, androgen receptor genepolymorphism (SNP rs6152) and clinical characteristics of benign prostatic hyperplasia and prostate cancer. Methods Overall, 309 male subjects with prostate disease (BPH or CaP) were examined. We evaluated the standard grades of AGA (I-VII) by Hamilton-Norwood classification and 195 patients were also assessed by phototrichogram. Prostate specific antigen (PSA) and testosterone levels were also measured. Polymorphism rs6152 of the androgen receptor was evaluated from blood samples by PCR-RFLP. Data werestatistically evaluated. Results The expected positive correlation between age and AGA grade and the expected negative correlation between hair density and age and between anagen/telogen and AGA were found. A statistically significant di

Název v anglickém jazyce

Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer

Popis výsledku anglicky

Background Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen-dependent disorders. Objective To investigate the relationships between male androgenetic alopecia, androgen receptor genepolymorphism (SNP rs6152) and clinical characteristics of benign prostatic hyperplasia and prostate cancer. Methods Overall, 309 male subjects with prostate disease (BPH or CaP) were examined. We evaluated the standard grades of AGA (I-VII) by Hamilton-Norwood classification and 195 patients were also assessed by phototrichogram. Prostate specific antigen (PSA) and testosterone levels were also measured. Polymorphism rs6152 of the androgen receptor was evaluated from blood samples by PCR-RFLP. Data werestatistically evaluated. Results The expected positive correlation between age and AGA grade and the expected negative correlation between hair density and age and between anagen/telogen and AGA were found. A statistically significant di

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FO - Dermatovenerologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the European Academy of Dermatology and Venerology

ISSN

0926-9959

e-ISSN

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Svazek periodika

29

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

91-96

Kód UT WoS článku

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EID výsledku v databázi Scopus

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