In Vitro AuNPs' Cytotoxicity and Their Effect on Wound Healing
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154260" target="_blank" >RIV/61989592:15110/15:33154260 - isvavai.cz</a>
Výsledek na webu
<a href="http://cdn.intechopen.com/pdfs-wm/48665.pdf" target="_blank" >http://cdn.intechopen.com/pdfs-wm/48665.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/61132" target="_blank" >10.5772/61132</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
In Vitro AuNPs' Cytotoxicity and Their Effect on Wound Healing
Popis výsledku v původním jazyce
Recently, due to their unique properties, gold nanoparticles (AuNPs) have been used in many biological applications. However, little is known about their toxicity when they come into contact with a biological system. Based on the proposal that AuNPs canhave a positive effect on wound healing, the present study investigated the influence of negatively-charged-surface AuNPs (average diameter 25-50 nm) on the viability of normal human dermal fibroblasts (NHDF) and normal human epidermal keratinocytes (NHEK). Moreover, we evaluated the effect of AuNPs on the secretion of proteins involved in wound healing, such as interleukin-8 and -12 (IL-8, IL-12), tumour necrosis factor-alpha (TNF-?), vascular endothelial growth factor (VEGF), basic fibroblast grow factor (bFGF), and granulocyte-macrophage colony-stimulating factor (GM-CSF). The results showed that AuNPs were not toxic to NHDF and NHEK. They showed a decrease in AuNPs' production of pro-inflammatory cytokines IL-6, IL-12 and TNF-?, as
Název v anglickém jazyce
In Vitro AuNPs' Cytotoxicity and Their Effect on Wound Healing
Popis výsledku anglicky
Recently, due to their unique properties, gold nanoparticles (AuNPs) have been used in many biological applications. However, little is known about their toxicity when they come into contact with a biological system. Based on the proposal that AuNPs canhave a positive effect on wound healing, the present study investigated the influence of negatively-charged-surface AuNPs (average diameter 25-50 nm) on the viability of normal human dermal fibroblasts (NHDF) and normal human epidermal keratinocytes (NHEK). Moreover, we evaluated the effect of AuNPs on the secretion of proteins involved in wound healing, such as interleukin-8 and -12 (IL-8, IL-12), tumour necrosis factor-alpha (TNF-?), vascular endothelial growth factor (VEGF), basic fibroblast grow factor (bFGF), and granulocyte-macrophage colony-stimulating factor (GM-CSF). The results showed that AuNPs were not toxic to NHDF and NHEK. They showed a decrease in AuNPs' production of pro-inflammatory cytokines IL-6, IL-12 and TNF-?, as
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Nanobiomedicine
ISSN
1849-5435
e-ISSN
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Svazek periodika
2
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
HR - Chorvatská republika
Počet stran výsledku
7
Strana od-do
1-7
Kód UT WoS článku
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EID výsledku v databázi Scopus
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