Correlations of neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with biomarkers of atherosclerosis risk and inflammatory response in patients with a history of breast cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33155539" target="_blank" >RIV/61989592:15110/15:33155539 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/15:10318808 RIV/00216208:11160/15:10318808 RIV/00179906:_____/15:10318808

Výsledek na webu

<a href="http://dx.doi.org/10.1515/pterid-2015-0009" target="_blank" >http://dx.doi.org/10.1515/pterid-2015-0009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/pterid-2015-0009" target="_blank" >10.1515/pterid-2015-0009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Correlations of neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with biomarkers of atherosclerosis risk and inflammatory response in patients with a history of breast cancer

Popis výsledku v původním jazyce

The aim of the present study was to evaluate the correlations of peripheral blood cell count (PBC)-derived ratios with neopterin concentration and biomarkers of atherosclerosis risk in patients with history of breast cancer. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) were calculated in three cohorts of patients with a history of breast cancer and in controls. Significant differences were observed between PBC-derived ratios obtained from automated and manual counts. NLR and PLR were significantly higher and LMR was significantly lower in patients. NLR and PLR correlated positively with each other and negatively with LMR. NLR exhibited a significant correlation with age, glucose and C-reactive protein (CRP) concentrations, whereas LMR correlated negatively with CRP. With the exception of a correlation between LMR and urinary or serum neopterin concentrations in controls, no other correlation between neopterin concentrations and PBC-derived ratios was observed. NLR GREATER-THAN OR EQUAL TO3 was a significant predictor of poor survival, but neither urinary neopterin GREATER-THAN OR EQUAL TO205 μmol/mol creatinine, NLR GREATER-THAN OR EQUAL TO150 nor LMR GREATER-THAN OR EQUAL TO4.25 was significantly associated with survival. In conclusion, no consistent correlation was observed between urinary and serum neopterin concentrations and any of the PBC-derived ratios. In a cohort of breast cancer patients, a higher NLR predicted poor survival.

Název v anglickém jazyce

Correlations of neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with biomarkers of atherosclerosis risk and inflammatory response in patients with a history of breast cancer

Popis výsledku anglicky

The aim of the present study was to evaluate the correlations of peripheral blood cell count (PBC)-derived ratios with neopterin concentration and biomarkers of atherosclerosis risk in patients with history of breast cancer. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) were calculated in three cohorts of patients with a history of breast cancer and in controls. Significant differences were observed between PBC-derived ratios obtained from automated and manual counts. NLR and PLR were significantly higher and LMR was significantly lower in patients. NLR and PLR correlated positively with each other and negatively with LMR. NLR exhibited a significant correlation with age, glucose and C-reactive protein (CRP) concentrations, whereas LMR correlated negatively with CRP. With the exception of a correlation between LMR and urinary or serum neopterin concentrations in controls, no other correlation between neopterin concentrations and PBC-derived ratios was observed. NLR GREATER-THAN OR EQUAL TO3 was a significant predictor of poor survival, but neither urinary neopterin GREATER-THAN OR EQUAL TO205 μmol/mol creatinine, NLR GREATER-THAN OR EQUAL TO150 nor LMR GREATER-THAN OR EQUAL TO4.25 was significantly associated with survival. In conclusion, no consistent correlation was observed between urinary and serum neopterin concentrations and any of the PBC-derived ratios. In a cohort of breast cancer patients, a higher NLR predicted poor survival.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13564" target="_blank" >NT13564: Prediktivní faktory patologické odpovědi na neoadjuvantní chemoterapii u nemocných s karcinomem prsu a HER-2 pozitivním nebo triple negativním fenotypem</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pteridines

ISSN

0933-4807

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

161-172

Kód UT WoS článku

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EID výsledku v databázi Scopus

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