Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33156620" target="_blank" >RIV/61989592:15110/15:33156620 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking

Popis výsledku v původním jazyce

Chemokine receptors and their ligands, key mediators of immune cell trafficking, have been critically involved in chronic lung diseases and their potential as therapeutic targets is currently being widely investigated. The discovery that chemokine receptors/chemokines, typically expressed by immune cells, are also expressed in structural lung cells reinforces significantly the evidence about their potential to mediate processes towards the restoration of normal lung functions. Besides cell migration, chemokine receptors and their ligands have been shown to regulate also other functions in the lung tissue, such as cell proliferation, mucin secretion, and collagen synthesis. Thus chemokine receptors/chemokines contribute not only to immune responses in the lung, but play a critical role also in the regulation of lung tissue repair and regeneration. This review aims to summarize current state-of-the-art on chemokine receptors and their ligands in chronic lung diseases and their therapeutic potential. Next, it aims to delineate the contribution of chemokine receptors to the processes leading to repair/regeneration of the lung tissue.

Název v anglickém jazyce

Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking

Popis výsledku anglicky

Chemokine receptors and their ligands, key mediators of immune cell trafficking, have been critically involved in chronic lung diseases and their potential as therapeutic targets is currently being widely investigated. The discovery that chemokine receptors/chemokines, typically expressed by immune cells, are also expressed in structural lung cells reinforces significantly the evidence about their potential to mediate processes towards the restoration of normal lung functions. Besides cell migration, chemokine receptors and their ligands have been shown to regulate also other functions in the lung tissue, such as cell proliferation, mucin secretion, and collagen synthesis. Thus chemokine receptors/chemokines contribute not only to immune responses in the lung, but play a critical role also in the regulation of lung tissue repair and regeneration. This review aims to summarize current state-of-the-art on chemokine receptors and their ligands in chronic lung diseases and their therapeutic potential. Next, it aims to delineate the contribution of chemokine receptors to the processes leading to repair/regeneration of the lung tissue.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT11117" target="_blank" >NT11117: Studium mediátorů fibrotizačních procesů u pacientů s difuzními plicními nemocemi a jejich aplikace v diagnostice</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of physiology. Lung cellular and molecular physiology

ISSN

1522-1504

e-ISSN

—

Svazek periodika

308

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

"L-603"-"L-618"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—