Perilipin-2: A new prospective biomarker for the diagnosis of acute myocardial ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33161910" target="_blank" >RIV/61989592:15110/16:33161910 - isvavai.cz</a>

Výsledek na webu

<a href="https://oatext.com/pdf/JTS-2-155.pdf" target="_blank" >https://oatext.com/pdf/JTS-2-155.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15761/JTS.1000155" target="_blank" >10.15761/JTS.1000155</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Perilipin-2: A new prospective biomarker for the diagnosis of acute myocardial ischemia

Popis výsledku v původním jazyce

Many scientists have been looking for faster, more accurate and confirmatory biomarkers of acute myocardial infarction (AMI). The aim has been to investigate an assay for the determination of perilipin-2 in human serum, and to check its clinical relevance as a marker of acute myocardial infarction (AMI First type). We have analytically and clinically examined a sandwich ELISA for perilipin-2 measurement. The Perilipin-2 serum level did not differentiate between men and women, but individuals with AMI showed to have higher concentrations of this marker. Perilipin-2 correlated with the serum TNF-α, ultra-sensitive (us) CRP, cystatinC and negatively with Apolipoprotein A1, HDL cholesterol and adiponectin. Using ROC analysis, it was found that the diagnostic efficiency of perilipin-2 was (excellent) and significantly higher than the others. We conclude that perilipin-2 is a very promising biomarker for the diagnosis of acute coronary syndrome.

Název v anglickém jazyce

Perilipin-2: A new prospective biomarker for the diagnosis of acute myocardial ischemia

Popis výsledku anglicky

Many scientists have been looking for faster, more accurate and confirmatory biomarkers of acute myocardial infarction (AMI). The aim has been to investigate an assay for the determination of perilipin-2 in human serum, and to check its clinical relevance as a marker of acute myocardial infarction (AMI First type). We have analytically and clinically examined a sandwich ELISA for perilipin-2 measurement. The Perilipin-2 serum level did not differentiate between men and women, but individuals with AMI showed to have higher concentrations of this marker. Perilipin-2 correlated with the serum TNF-α, ultra-sensitive (us) CRP, cystatinC and negatively with Apolipoprotein A1, HDL cholesterol and adiponectin. Using ROC analysis, it was found that the diagnostic efficiency of perilipin-2 was (excellent) and significantly higher than the others. We conclude that perilipin-2 is a very promising biomarker for the diagnosis of acute coronary syndrome.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Translational Science

ISSN

2059-268X

e-ISSN

—

Svazek periodika

2

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

297-300

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—