Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73577778" target="_blank" >RIV/61989592:15110/17:73577778 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/17:10363462 RIV/00098892:_____/17:N0000039

Výsledek na webu

<a href="https://obd.upol.cz/id_publ/333154559" target="_blank" >https://obd.upol.cz/id_publ/333154559</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00498254.2016.1195028" target="_blank" >10.1080/00498254.2016.1195028</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities

Popis výsledku v původním jazyce

The possibility of interaction of isoflavonoids with concomitantly taken drugs to determined isoflavonoids safety was studied. Inhibition of nine forms of cytochrome P450 (CYP3A4, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2C9, CYP2D6 and CYP2E1) by 12 isoflavonoids (daidzein, genistein, biochanin A, formononetin, glycitein, equol and six glucosides, daidzin, puerarin, genistin, sissotrin, ononin and glycitin) was studied systematically. The most potent inhibitors were genistein and daidzein inhibiting noncompetitively the CYP2C9 with Ki of 35.95 ± 6.96 and 60.56 ± 3.53 umol/l and CYP3A4 (inhibited by genistein with Ki of 23.25 ± 5.85 umol/l also by a noncompetitive mechanism). Potent inhibition of CYP3A4 was observed also with biochanin A (Ki of 57.69 ± 2.36 umol/l) and equol (Ki of 38.47 ± 2.32 umol/l). Genistein and daidzein inhibit noncompetitively CYP3A4 and CYP2C9. With plasma levels in micromolar range, a clinically important interaction with concomitantly taken drugs does not seem to be probable.

Název v anglickém jazyce

Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities

Popis výsledku anglicky

The possibility of interaction of isoflavonoids with concomitantly taken drugs to determined isoflavonoids safety was studied. Inhibition of nine forms of cytochrome P450 (CYP3A4, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2C9, CYP2D6 and CYP2E1) by 12 isoflavonoids (daidzein, genistein, biochanin A, formononetin, glycitein, equol and six glucosides, daidzin, puerarin, genistin, sissotrin, ononin and glycitin) was studied systematically. The most potent inhibitors were genistein and daidzein inhibiting noncompetitively the CYP2C9 with Ki of 35.95 ± 6.96 and 60.56 ± 3.53 umol/l and CYP3A4 (inhibited by genistein with Ki of 23.25 ± 5.85 umol/l also by a noncompetitive mechanism). Potent inhibition of CYP3A4 was observed also with biochanin A (Ki of 57.69 ± 2.36 umol/l) and equol (Ki of 38.47 ± 2.32 umol/l). Genistein and daidzein inhibit noncompetitively CYP3A4 and CYP2C9. With plasma levels in micromolar range, a clinically important interaction with concomitantly taken drugs does not seem to be probable.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centrum interakcí potravních doplňků s léčivy a nutrigenetiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Xenobiotica

ISSN

0049-8254

e-ISSN

—

Svazek periodika

47

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

324-331

Kód UT WoS článku

000395347600007

EID výsledku v databázi Scopus

2-s2.0-84975109070