Androgen Receptor as a Target for Epigenetic Therapy of Castration Resistant Prostate Cancer (CRPC)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73582371" target="_blank" >RIV/61989592:15110/17:73582371 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Androgen Receptor as a Target for Epigenetic Therapy of Castration Resistant Prostate Cancer (CRPC)

Popis výsledku v původním jazyce

Androgen and androgen receptor play key roles in the development of the prostate gland as well as the prostate cancer. Evidence from basic research and clinical studies indicates that androgen receptor and AR-dependent transcription remain activate in castration resistant prostate cancer. Alterations in the androgen receptor signaling axis are central to castration resistant prostate cancer progression, and have uncovered complex mechanisms by which AR and other components of the AR signaling axis affect, and are affected by different type of coregulatory proteins as well as epigenetic modifications such as DNA methylation and enzymes effecting histone modifications.

Název v anglickém jazyce

Androgen Receptor as a Target for Epigenetic Therapy of Castration Resistant Prostate Cancer (CRPC)

Popis výsledku anglicky

Androgen and androgen receptor play key roles in the development of the prostate gland as well as the prostate cancer. Evidence from basic research and clinical studies indicates that androgen receptor and AR-dependent transcription remain activate in castration resistant prostate cancer. Alterations in the androgen receptor signaling axis are central to castration resistant prostate cancer progression, and have uncovered complex mechanisms by which AR and other components of the AR signaling axis affect, and are affected by different type of coregulatory proteins as well as epigenetic modifications such as DNA methylation and enzymes effecting histone modifications.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LO1304" target="_blank" >LO1304: Podpora udržitelnosti Ústavu molekulární a translační medicíny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Prostate Cancer

ISBN

978-93-86337-47-4

Počet stran výsledku

24

Strana od-do

2-25

Počet stran knihy

76

Název nakladatele

Avid Science

Místo vydání

Telangana

Kód UT WoS kapitoly

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