Benzoxazole Derivatives as Promising Antitubercular Agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591160" target="_blank" >RIV/61989592:15110/18:73591160 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/18:73591160

Výsledek na webu

<a href="http://dx.doi.org/10.1002/slct.201800631" target="_blank" >http://dx.doi.org/10.1002/slct.201800631</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/slct.201800631" target="_blank" >10.1002/slct.201800631</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Benzoxazole Derivatives as Promising Antitubercular Agents

Popis výsledku v původním jazyce

Tuberculosis (TB) is an infectious disease caused predominantly by bacillus Mycobacterium tuberculosis (MTB). The increasing prevalence of multidrug-resistant MTB necessitates the discovery and development of alternative drugs against tuberculosis with a new mechanism of action. Over the past years, several benzoxazole derivatives have been synthesized and screened for their biological activity. Interestingly, some of them had promising antitubercular activity. Despite that, none of the benzoxazole derivatives has entered the phase of the preclinical hit-to-lead optimization step in anti-TB research. In this review, we are summarizing recently published articles that evaluate the potency of benzoxazole heterocycle in the development of novel anti-TB agents and outlined the future aspects of this promising heterocycle.

Název v anglickém jazyce

Benzoxazole Derivatives as Promising Antitubercular Agents

Popis výsledku anglicky

Tuberculosis (TB) is an infectious disease caused predominantly by bacillus Mycobacterium tuberculosis (MTB). The increasing prevalence of multidrug-resistant MTB necessitates the discovery and development of alternative drugs against tuberculosis with a new mechanism of action. Over the past years, several benzoxazole derivatives have been synthesized and screened for their biological activity. Interestingly, some of them had promising antitubercular activity. Despite that, none of the benzoxazole derivatives has entered the phase of the preclinical hit-to-lead optimization step in anti-TB research. In this review, we are summarizing recently published articles that evaluate the potency of benzoxazole heterocycle in the development of novel anti-TB agents and outlined the future aspects of this promising heterocycle.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ChemistrySelect

ISSN

2365-6549

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

4653-4662

Kód UT WoS článku

000431625900013

EID výsledku v databázi Scopus

2-s2.0-85046677486