Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591231" target="_blank" >RIV/61989592:15110/18:73591231 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.taap.2018.06.025" target="_blank" >http://dx.doi.org/10.1016/j.taap.2018.06.025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.taap.2018.06.025" target="_blank" >10.1016/j.taap.2018.06.025</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.

Popis výsledku v původním jazyce

CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). EETs are very biologically active molecules. They promote proliferation and inhibit apoptosis. Peroxisome proliferator-activated receptor α (PPARα) play role in regulation of CYP epoxygenases and sEH. PPARα is the ligand-dependent transcriptional factor which is activated by various compounds, including fibrates. The results demonstrate that the effect of fibrates on arachidonic acid-metabolizing enzymes expression is concentration-dependent. Although CYP2C8 expression is downregulated by the fibrates treatment, the results reveal that changes in CYP2J2 / sEH ratio are closely associated with cell proliferation.

Název v anglickém jazyce

Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.

Popis výsledku anglicky

CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). EETs are very biologically active molecules. They promote proliferation and inhibit apoptosis. Peroxisome proliferator-activated receptor α (PPARα) play role in regulation of CYP epoxygenases and sEH. PPARα is the ligand-dependent transcriptional factor which is activated by various compounds, including fibrates. The results demonstrate that the effect of fibrates on arachidonic acid-metabolizing enzymes expression is concentration-dependent. Although CYP2C8 expression is downregulated by the fibrates treatment, the results reveal that changes in CYP2J2 / sEH ratio are closely associated with cell proliferation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LO1304" target="_blank" >LO1304: Podpora udržitelnosti Ústavu molekulární a translační medicíny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

TOXICOLOGY AND APPLIED PHARMACOLOGY

ISSN

0041-008X

e-ISSN

—

Svazek periodika

2018

Číslo periodika v rámci svazku

září

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

156-163

Kód UT WoS článku

000442193300016

EID výsledku v databázi Scopus

2-s2.0-85049556840