Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73593438" target="_blank" >RIV/61989592:15110/18:73593438 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60077344:_____/19:00518828
Výsledek na webu
<a href="https://link.springer.com/article/10.1007/s00294-018-0904-y" target="_blank" >https://link.springer.com/article/10.1007/s00294-018-0904-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00294-018-0904-y" target="_blank" >10.1007/s00294-018-0904-y</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus
Popis výsledku v původním jazyce
The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Název v anglickém jazyce
Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus
Popis výsledku anglicky
The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
10303 - Particles and field physics
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current Genetics
ISSN
0172-8083
e-ISSN
—
Svazek periodika
65
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
22
Strana od-do
539-560
Kód UT WoS článku
000461396800028
EID výsledku v databázi Scopus
2-s2.0-85056814450