Content of distinct metals in periprosthetic tissues and pseudosynovial joint fluid in patients with total joint arthroplasty

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73597787" target="_blank" >RIV/61989592:15110/19:73597787 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/19:73597787

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.34137" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.34137</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.b.34137" target="_blank" >10.1002/jbm.b.34137</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Content of distinct metals in periprosthetic tissues and pseudosynovial joint fluid in patients with total joint arthroplasty

Popis výsledku v původním jazyce

This prospective study examined the content of metals released from total joint arthroplasty into joint fluid, whole blood and periprosthetic tissues. We determined the levels of Ti, V, Nb, Co, Cr, and Mo, using inductively coupled plasma mass spectrometry, in samples from patients who underwent reoperation of total hip or knee arthroplasty. All of the patients (n = 117) included in the study had either metal on polyethylene or ceramic on polyethylene-bearing pairs. First, our results conclusively showed that the majority of released metals were deposited in periprosthetic tissues. In this context, the bloodstream turned out to be an ineffective biomarker of the effects occurring in local tissues. Second, there was a clear time-dependent nature of metallic accumulation. Based on our extensive dataset, we found significantly elevated levels of the released metals in joint fluid and periprosthetic tissues originating from loosened implants compared to stable ones, as well as recognizable differences between the groups with stable implants and aseptic loosening. Finally, it was proved that the concentrations of metals decreased dependent on the distance of the tissue from the implant.

Název v anglickém jazyce

Content of distinct metals in periprosthetic tissues and pseudosynovial joint fluid in patients with total joint arthroplasty

Popis výsledku anglicky

This prospective study examined the content of metals released from total joint arthroplasty into joint fluid, whole blood and periprosthetic tissues. We determined the levels of Ti, V, Nb, Co, Cr, and Mo, using inductively coupled plasma mass spectrometry, in samples from patients who underwent reoperation of total hip or knee arthroplasty. All of the patients (n = 117) included in the study had either metal on polyethylene or ceramic on polyethylene-bearing pairs. First, our results conclusively showed that the majority of released metals were deposited in periprosthetic tissues. In this context, the bloodstream turned out to be an ineffective biomarker of the effects occurring in local tissues. Second, there was a clear time-dependent nature of metallic accumulation. Based on our extensive dataset, we found significantly elevated levels of the released metals in joint fluid and periprosthetic tissues originating from loosened implants compared to stable ones, as well as recognizable differences between the groups with stable implants and aseptic loosening. Finally, it was proved that the concentrations of metals decreased dependent on the distance of the tissue from the implant.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

ISSN

1552-4973

e-ISSN

—

Svazek periodika

107

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

454-462

Kód UT WoS článku

000455252200025

EID výsledku v databázi Scopus

2-s2.0-85044949749