Cdc7 kinase stimulates Aurora B kinase in M-phase

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73599271" target="_blank" >RIV/61989592:15110/19:73599271 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-019-54738-2.pdf" target="_blank" >https://www.nature.com/articles/s41598-019-54738-2.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-019-54738-2" target="_blank" >10.1038/s41598-019-54738-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cdc7 kinase stimulates Aurora B kinase in M-phase

Popis výsledku v původním jazyce

The conserved serine-threonine kinase, Cdc7-Dbf4, phosphorylates Mcm in the pre-Replicative Complex (pre-RC) and facilitates recruitment of other replication factors including Cdc45 for initiation of DNA replication1–8. Cdc7 forms a complex with an activation subunit, Dbf4/ASK, to become an active kinase9–11. Cdc7 also plays a role in activation of replication checkpoint pathway (ATR-Claspin-Chk1 pathway in vertebrates12–16). Recent studies show that Cdc7 kinase plays roles in various chromosome transactions including meiotic recombination, meiosis, trans-lesion DNA synthesis, and histone modifcation17,18. Cdc7 also interacts with various chromosome markers including HP1 that recognizes methylated lysine 9 of histone H3 and with centromere proteins19,20. Cdc7 also phosphorylates Histone H3 at threonine-45 as a part of replication stress responses21.

Název v anglickém jazyce

Cdc7 kinase stimulates Aurora B kinase in M-phase

Popis výsledku anglicky

The conserved serine-threonine kinase, Cdc7-Dbf4, phosphorylates Mcm in the pre-Replicative Complex (pre-RC) and facilitates recruitment of other replication factors including Cdc45 for initiation of DNA replication1–8. Cdc7 forms a complex with an activation subunit, Dbf4/ASK, to become an active kinase9–11. Cdc7 also plays a role in activation of replication checkpoint pathway (ATR-Claspin-Chk1 pathway in vertebrates12–16). Recent studies show that Cdc7 kinase plays roles in various chromosome transactions including meiotic recombination, meiosis, trans-lesion DNA synthesis, and histone modifcation17,18. Cdc7 also interacts with various chromosome markers including HP1 that recognizes methylated lysine 9 of histone H3 and with centromere proteins19,20. Cdc7 also phosphorylates Histone H3 at threonine-45 as a part of replication stress responses21.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

09.12.2019

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

"nestránkováno"

Kód UT WoS článku

000501757000002

EID výsledku v databázi Scopus

2-s2.0-85076336995