Association of TGF-β3 and ANXA11 With Pulmonary Sarcoidosis in Greek Population
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73601272" target="_blank" >RIV/61989592:15110/20:73601272 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00098892:_____/20:N0000109
Výsledek na webu
<a href="https://www.tandfonline.com/doi/full/10.1080/17476348.2020.1784729" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17476348.2020.1784729</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/17476348.2020.1784729" target="_blank" >10.1080/17476348.2020.1784729</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Association of TGF-β3 and ANXA11 With Pulmonary Sarcoidosis in Greek Population
Popis výsledku v původním jazyce
Background In sarcoidosis, the direction and intensity of immunological reactions involved in disease pathophysiology is affected by variation in the genes coding for effector and regulatory molecules with immune functions. This study, therefore, investigates polymorphic variants in genes involved in inflammation, immune reactions, and granuloma formation in context of their plausible association with sarcoidosis, with specific focus on Greek population. Methods A total of 18 single-nucleotide polymorphisms (SNPs) were genotyped in Greek patients with pulmonary sarcoidosis (n = 103) and in healthy Greek control subjects (n = 100) using multiplexed MassARRAY (MassARRAY (R)) iPLEX assay based on MALDI-TOF mass spectrometry. ResultsTGF-beta 3 rs3917200*G variant was associated with sarcoidosis (OR: 3.04 [95% CI: 1.98-4.69],p = 2.76*10(-7)). Further,ANXA11rs1049550*A variant was associated with sarcoidosis (OR: 0.59 [0.39-0.89],p = 0.01). Conclusions This first study of genetic variation of immune-related genes in Greek patients with sarcoidosis brings to attention a novel disease 'susceptibility' factor:TGF-beta 3rs3917200*G allele. It also confirms previously reported 'protective' association between sarcoidosis and functional variantANXA11rs1049550*A. Further work is required to validate these findings and to expand investigation of their plausible relationship with clinical course of the disease.
Název v anglickém jazyce
Association of TGF-β3 and ANXA11 With Pulmonary Sarcoidosis in Greek Population
Popis výsledku anglicky
Background In sarcoidosis, the direction and intensity of immunological reactions involved in disease pathophysiology is affected by variation in the genes coding for effector and regulatory molecules with immune functions. This study, therefore, investigates polymorphic variants in genes involved in inflammation, immune reactions, and granuloma formation in context of their plausible association with sarcoidosis, with specific focus on Greek population. Methods A total of 18 single-nucleotide polymorphisms (SNPs) were genotyped in Greek patients with pulmonary sarcoidosis (n = 103) and in healthy Greek control subjects (n = 100) using multiplexed MassARRAY (MassARRAY (R)) iPLEX assay based on MALDI-TOF mass spectrometry. ResultsTGF-beta 3 rs3917200*G variant was associated with sarcoidosis (OR: 3.04 [95% CI: 1.98-4.69],p = 2.76*10(-7)). Further,ANXA11rs1049550*A variant was associated with sarcoidosis (OR: 0.59 [0.39-0.89],p = 0.01). Conclusions This first study of genetic variation of immune-related genes in Greek patients with sarcoidosis brings to attention a novel disease 'susceptibility' factor:TGF-beta 3rs3917200*G allele. It also confirms previously reported 'protective' association between sarcoidosis and functional variantANXA11rs1049550*A. Further work is required to validate these findings and to expand investigation of their plausible relationship with clinical course of the disease.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30203 - Respiratory systems
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Expert Review of Respiratory Medicine
ISSN
1747-6348
e-ISSN
—
Svazek periodika
14
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
5
Strana od-do
1065-1069
Kód UT WoS článku
000547843500001
EID výsledku v databázi Scopus
2-s2.0-85087841699