Low Levels of Glycemia within the First 48 Hours after Mechanical Thrombectomy for Acute Ischemic Stroke May be Associated with Better Clinical Outcome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73603750" target="_blank" >RIV/61989592:15110/20:73603750 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/44555601:13450/20:43895896 RIV/00098892:_____/20:N0000117

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/31987735/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/31987735/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104621" target="_blank" >10.1016/j.jstrokecerebrovasdis.2019.104621</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low Levels of Glycemia within the First 48 Hours after Mechanical Thrombectomy for Acute Ischemic Stroke May be Associated with Better Clinical Outcome

Popis výsledku v původním jazyce

Introduction: Many different factors may have an impact on clinical outcome after mechanical thrombectomy (MT) for acute ischemic stroke (AIS). We aimed to investigate levels of serum glycemia (GLY) within the first 48 hours after MT. Subjects and Methods: Consecutive AIS patients were enrolled in the retrospective bi-center study. Neurological deficit was assessed with National Institutes of Health Stroke Scale (NIHSS) and functional outcome after 3 months with modified Rankin scale with a score 0-2 for good outcome. Presence of symptomatic intracerebral hemorrhage was assessed according to the SITS- MOST criteria. Results: In total, 868 patients (442 males, mean age 69.7 +/- 12.2 years) with a median of admission NIHSS 17 points were enrolled in the study and 253 (29.1%) of them were diabetics. Recanalization was reached in 758 (87.3%) patients. Patients with good outcome (412, 47.5%) had lower median of GLY (6.5 versus 7.4 mmol/L, P &lt; .0001) within the first 48 hours after MT. Similar results were found also in diabetics (8.1 versus 9.6 mmol/L, P &lt; .0001) and in patients with achieved recanalization (6.5 versus 7.5 mmol/L, P &lt; .0001). Multivariate regression analysis with adjustment for potential confounders showed median of GLY (P = .0001, odds ratio: 0.830, 95% confidence interval: 0.755-0.913) as a predictor of good outcome after MT. Conclusion: Lower levels of GLY within the first 48 hours after MT may be associated with better functional outcome after 3 months.

Název v anglickém jazyce

Low Levels of Glycemia within the First 48 Hours after Mechanical Thrombectomy for Acute Ischemic Stroke May be Associated with Better Clinical Outcome

Popis výsledku anglicky

Introduction: Many different factors may have an impact on clinical outcome after mechanical thrombectomy (MT) for acute ischemic stroke (AIS). We aimed to investigate levels of serum glycemia (GLY) within the first 48 hours after MT. Subjects and Methods: Consecutive AIS patients were enrolled in the retrospective bi-center study. Neurological deficit was assessed with National Institutes of Health Stroke Scale (NIHSS) and functional outcome after 3 months with modified Rankin scale with a score 0-2 for good outcome. Presence of symptomatic intracerebral hemorrhage was assessed according to the SITS- MOST criteria. Results: In total, 868 patients (442 males, mean age 69.7 +/- 12.2 years) with a median of admission NIHSS 17 points were enrolled in the study and 253 (29.1%) of them were diabetics. Recanalization was reached in 758 (87.3%) patients. Patients with good outcome (412, 47.5%) had lower median of GLY (6.5 versus 7.4 mmol/L, P &lt; .0001) within the first 48 hours after MT. Similar results were found also in diabetics (8.1 versus 9.6 mmol/L, P &lt; .0001) and in patients with achieved recanalization (6.5 versus 7.5 mmol/L, P &lt; .0001). Multivariate regression analysis with adjustment for potential confounders showed median of GLY (P = .0001, odds ratio: 0.830, 95% confidence interval: 0.755-0.913) as a predictor of good outcome after MT. Conclusion: Lower levels of GLY within the first 48 hours after MT may be associated with better functional outcome after 3 months.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV17-30101A" target="_blank" >NV17-30101A: Rizikové faktory ischemické cévní mozkové příhody u mladých pacientů: vztah k epidemiologickým, sociálním, ekonomickým parametrům a životnímu stylu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Stroke &amp; Cerebrovascular Diseases

ISSN

1052-3057

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"'104621(1)'"-"'104621(8)'"

Kód UT WoS článku

000519193000035

EID výsledku v databázi Scopus

2-s2.0-85078337880