Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73607908" target="_blank" >RIV/61989592:15110/21:73607908 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/21:N0000054

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238289/pdf/medi-100-e26356.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238289/pdf/medi-100-e26356.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MD.0000000000026356" target="_blank" >10.1097/MD.0000000000026356</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity

Popis výsledku v původním jazyce

Abstract In dystonic and spastic movement disorders, abnormalities of motor control and somatosensory processing as well as cortical modulations associated with clinical improvement after botulinum toxin A (BoNT-A) treatment have been reported, but electrophysiological evidence remains controversial. In the present observational study, we aimed to uncover central correlates of post-stroke spasticity (PSS) and BoNT-A-related changes in the sensorimotor cortex by investigating the cortical components of somatosensory evoked potentials (SEPs). Thirty-one chronic stroke patients with PSS of the upper limb were treated with BoNT-A application into the affected muscles and physiotherapy. Clinical and electrophysiological evaluations were performed just before BoNT-A application (W0), then 4 weeks (W4) and 11weeks (W11) later. PSS was evaluated with the modified Ashworth scale (MAS). Median nerve SEPs were examined in both upper limbs with subsequent statistical analysis of the peak-to-peak amplitudes of precentral P22/N30 and postcentral N20/P23 components. At baseline (W0), postcentral SEPs were significantly lower over the affected cortex. At follow up, cortical SEPs did not show any significant changes attributable to BoNT-A and/or physiotherapy, despite clear clinical improvement. Our results imply that conventional SEPs are of limited value in evaluating cortical changes after BoNT-A treatment and further studies are needed to elucidate its central actions. Abbreviations: ADL = activities of daily living, BoNT-A = botulinum toxin A, CNS = central nervous system, fMRI = functional magnetic resonance imaging, IQR = interquartile range, MAS = modified Ashworth scale, PPC = posterior parietal cortex, PSS = post-stroke spasticity, SD = standard deviation, SEPs = somatosensory evoked potentials.

Název v anglickém jazyce

Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity

Popis výsledku anglicky

Abstract In dystonic and spastic movement disorders, abnormalities of motor control and somatosensory processing as well as cortical modulations associated with clinical improvement after botulinum toxin A (BoNT-A) treatment have been reported, but electrophysiological evidence remains controversial. In the present observational study, we aimed to uncover central correlates of post-stroke spasticity (PSS) and BoNT-A-related changes in the sensorimotor cortex by investigating the cortical components of somatosensory evoked potentials (SEPs). Thirty-one chronic stroke patients with PSS of the upper limb were treated with BoNT-A application into the affected muscles and physiotherapy. Clinical and electrophysiological evaluations were performed just before BoNT-A application (W0), then 4 weeks (W4) and 11weeks (W11) later. PSS was evaluated with the modified Ashworth scale (MAS). Median nerve SEPs were examined in both upper limbs with subsequent statistical analysis of the peak-to-peak amplitudes of precentral P22/N30 and postcentral N20/P23 components. At baseline (W0), postcentral SEPs were significantly lower over the affected cortex. At follow up, cortical SEPs did not show any significant changes attributable to BoNT-A and/or physiotherapy, despite clear clinical improvement. Our results imply that conventional SEPs are of limited value in evaluating cortical changes after BoNT-A treatment and further studies are needed to elucidate its central actions. Abbreviations: ADL = activities of daily living, BoNT-A = botulinum toxin A, CNS = central nervous system, fMRI = functional magnetic resonance imaging, IQR = interquartile range, MAS = modified Ashworth scale, PPC = posterior parietal cortex, PSS = post-stroke spasticity, SD = standard deviation, SEPs = somatosensory evoked potentials.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV17-29452A" target="_blank" >NV17-29452A: Modulace senzorimotorických sítí při cílené terapii spasticity po ischemickém iktu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MEDICINE

ISSN

0025-7974

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

100

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

"nestránkováno"

Kód UT WoS článku

000664672200028

EID výsledku v databázi Scopus

2-s2.0-85109017978