Arterial Hypertension and Risk of Recurrent Event in Young Ischemic Stroke Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73608556" target="_blank" >RIV/61989592:15110/21:73608556 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/21:N0000079

Výsledek na webu

<a href="https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/abs/arterial-hypertension-and-risk-of-recurrent-event-in-young-ischemic-stroke-patients/89035C28C2559F258834490FB3973992" target="_blank" >https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/abs/arterial-hypertension-and-risk-of-recurrent-event-in-young-ischemic-stroke-patients/89035C28C2559F258834490FB3973992</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/cjn.2020.200" target="_blank" >10.1017/cjn.2020.200</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Arterial Hypertension and Risk of Recurrent Event in Young Ischemic Stroke Patients

Popis výsledku v původním jazyce

Introduction: In young patients, the cause of ischemic stroke (IS) remains often cryptogenic despite presence of traditional vascular risk factors (VRFs). Since arterial hypertension (AH) is considered the most important one, we aimed to evaluate the impact of AH and blood pressure (BP) levels after discharge on risk of recurrent IS (RIS) in young patients. Methods: The study set consisted of acute IS patients &lt; 50 years of age enrolled in the prospective Heart and Ischemic STrOke Relationship studY registered on ClinicalTrials.gov (NCT01541163). Cause of IS was assessed according to the ASCOD classification. Results: Out of 319 enrolled patients &lt;50 years of age (179 males, mean age 41.1 ± 7.8 years), AH was present in 120 (37.6%) of them. No difference was found in the rates of etiological subtypes of IS between patients with and without AH. Patients with AH were older, had more VRF, used more frequently antiplatelets prior IS, and had more RIS (10 vs. 1%, p = 0.002) during a follow-up (FUP) with median of 25 months. Multivariate logistic regression stepwise model showed the prior use of antiplatelets as only predictor of RIS (p = 0.011, OR: 6.125; 95% CI: 1.510–24.837). Patients with elevated BP levels on BP Holter 1 month after discharge did not have increased rate of RIS during FUP (3.8 vs. 1.7%, p = 1.000). Conclusion: AH occurred in 37.6% of young IS patients. Patients with AH had more frequently RIS. Prior use of antiplatelets was found only predictor of RIS in young IS patients with AH.

Název v anglickém jazyce

Arterial Hypertension and Risk of Recurrent Event in Young Ischemic Stroke Patients

Popis výsledku anglicky

Introduction: In young patients, the cause of ischemic stroke (IS) remains often cryptogenic despite presence of traditional vascular risk factors (VRFs). Since arterial hypertension (AH) is considered the most important one, we aimed to evaluate the impact of AH and blood pressure (BP) levels after discharge on risk of recurrent IS (RIS) in young patients. Methods: The study set consisted of acute IS patients &lt; 50 years of age enrolled in the prospective Heart and Ischemic STrOke Relationship studY registered on ClinicalTrials.gov (NCT01541163). Cause of IS was assessed according to the ASCOD classification. Results: Out of 319 enrolled patients &lt;50 years of age (179 males, mean age 41.1 ± 7.8 years), AH was present in 120 (37.6%) of them. No difference was found in the rates of etiological subtypes of IS between patients with and without AH. Patients with AH were older, had more VRF, used more frequently antiplatelets prior IS, and had more RIS (10 vs. 1%, p = 0.002) during a follow-up (FUP) with median of 25 months. Multivariate logistic regression stepwise model showed the prior use of antiplatelets as only predictor of RIS (p = 0.011, OR: 6.125; 95% CI: 1.510–24.837). Patients with elevated BP levels on BP Holter 1 month after discharge did not have increased rate of RIS during FUP (3.8 vs. 1.7%, p = 1.000). Conclusion: AH occurred in 37.6% of young IS patients. Patients with AH had more frequently RIS. Prior use of antiplatelets was found only predictor of RIS in young IS patients with AH.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV17-30101A" target="_blank" >NV17-30101A: Rizikové faktory ischemické cévní mozkové příhody u mladých pacientů: vztah k epidemiologickým, sociálním, ekonomickým parametrům a životnímu stylu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

ISSN

0317-1671

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

"358 "- 364

Kód UT WoS článku

000644429600009

EID výsledku v databázi Scopus

2-s2.0-85104968252