Bone invasion by oral squamous cell carcinoma
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73609490" target="_blank" >RIV/61989592:15110/21:73609490 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.prolekare.cz/en/journals/acta-chirurgiae-plasticae/2021-3-24/bone-invasion-by-oral-squamous-cell-carcinoma-128700" target="_blank" >https://www.prolekare.cz/en/journals/acta-chirurgiae-plasticae/2021-3-24/bone-invasion-by-oral-squamous-cell-carcinoma-128700</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.48095/ccachp2021139" target="_blank" >10.48095/ccachp2021139</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Bone invasion by oral squamous cell carcinoma
Popis výsledku v původním jazyce
With regards to the anatomical relationships in the mouth, oral squamous cell carcinoma can invade the maxilla or the mandible. According to the TNM system, tumours that invade through cortical bone are classified as T4a, stage IVA. Bone invasion by oral squamous cell carcinoma most often occurs in tumours close to the bone or in larger and more advanced tumours. It is considered an adverse prognostic factor and it is often a diagnostic and therapeutic problem. Destruction of the bone tissue is mediated by activated osteoclasts rather than directly by carcinoma. Tumor necrosis factors - receptor activator of NF-kB (RANK), receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) - play an important role in osteoclastogenesis. According to histological point of view, there are three patterns of bone invasion - erosive, mixed and infiltrative. The most commonly used imaging techniques when evaluating bone invasion by oral squamous cell carcinoma include CT and MRI. PURPOSE: This review is focused on the cellular and molecular mechanisms, histological patterns and detection methods of bone invasion caused by oral squamous cell carcinoma.
Název v anglickém jazyce
Bone invasion by oral squamous cell carcinoma
Popis výsledku anglicky
With regards to the anatomical relationships in the mouth, oral squamous cell carcinoma can invade the maxilla or the mandible. According to the TNM system, tumours that invade through cortical bone are classified as T4a, stage IVA. Bone invasion by oral squamous cell carcinoma most often occurs in tumours close to the bone or in larger and more advanced tumours. It is considered an adverse prognostic factor and it is often a diagnostic and therapeutic problem. Destruction of the bone tissue is mediated by activated osteoclasts rather than directly by carcinoma. Tumor necrosis factors - receptor activator of NF-kB (RANK), receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) - play an important role in osteoclastogenesis. According to histological point of view, there are three patterns of bone invasion - erosive, mixed and infiltrative. The most commonly used imaging techniques when evaluating bone invasion by oral squamous cell carcinoma include CT and MRI. PURPOSE: This review is focused on the cellular and molecular mechanisms, histological patterns and detection methods of bone invasion caused by oral squamous cell carcinoma.
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
30208 - Dentistry, oral surgery and medicine
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Chirurgiae Plasticae
ISSN
0001-5423
e-ISSN
—
Svazek periodika
63
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
6
Strana od-do
139-144
Kód UT WoS článku
—
EID výsledku v databázi Scopus
2-s2.0-85122116304