Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73612826" target="_blank" >RIV/61989592:15110/22:73612826 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/22:73612826

Výsledek na webu

<a href="https://www.mdpi.com/1422-0067/23/8/4168/htm" target="_blank" >https://www.mdpi.com/1422-0067/23/8/4168/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms23084168" target="_blank" >10.3390/ijms23084168</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Popis výsledku v původním jazyce

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. It has many endogenous and exogenous inducers, and is closely connected with age, age-related pathologies, DNA damage, degenerative disorders, tumor suppression and activation, wound healing, and tissue repair. However, the literature is replete with contradictory findings concerning its triggering mechanisms, specific biomarkers, and detection protocols. This may be partly due to the wide range of cellular and in vivo animal or human models of accelerated aging that have been used to study senescence and test senolytic drugs. This review summarizes recent findings concerning senescence, presents some widely used cellular and animal senescence models, and briefly describes the best-known senolytic agents.

Název v anglickém jazyce

Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Popis výsledku anglicky

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. It has many endogenous and exogenous inducers, and is closely connected with age, age-related pathologies, DNA damage, degenerative disorders, tumor suppression and activation, wound healing, and tissue repair. However, the literature is replete with contradictory findings concerning its triggering mechanisms, specific biomarkers, and detection protocols. This may be partly due to the wide range of cellular and in vivo animal or human models of accelerated aging that have been used to study senescence and test senolytic drugs. This review summarizes recent findings concerning senescence, presents some widely used cellular and animal senescence models, and briefly describes the best-known senolytic agents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

26

Strana od-do

4168

Kód UT WoS článku

000786807500001

EID výsledku v databázi Scopus

2-s2.0-85127863967