Altered Plasma, Urine, and Tiissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73615455" target="_blank" >RIV/61989592:15110/22:73615455 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2072-6694/14/19/4622" target="_blank" >https://www.mdpi.com/2072-6694/14/19/4622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers14194622" target="_blank" >10.3390/cancers14194622</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered Plasma, Urine, and Tiissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

Popis výsledku v původním jazyce

Simple Summary: Renal cell carcinoma (RCC) is among the most common cancer types in both men and women, and its early detection significantly improves survival. Minimally-invasive blood- or urine-based tests may increase the RCC detection rate, especially before patients develop symptoms. Here, we report significant changes in concentrations of sulfatides and sphingomyelins in plasma and urine in RCC patients compared to healthy controls. For the first time, we present findings that similar alterations appear in the lipid profiles of body fluids and tissues in patients. We observe gradual changes in sulfatide and sphingomyelin concentrations with increasing tumor stage andgrade. We built binary classifiers that detect RCC based on plasma and urine lipidome dysregulationsand we show that the plasma lipidome alterations enable distinguishing between early-stage RCC and controls. Our results demonstrate the considerable potential of lipid screening in biofluids for RCC detection and monitoring in clinical settings.

Název v anglickém jazyce

Altered Plasma, Urine, and Tiissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

Popis výsledku anglicky

Simple Summary: Renal cell carcinoma (RCC) is among the most common cancer types in both men and women, and its early detection significantly improves survival. Minimally-invasive blood- or urine-based tests may increase the RCC detection rate, especially before patients develop symptoms. Here, we report significant changes in concentrations of sulfatides and sphingomyelins in plasma and urine in RCC patients compared to healthy controls. For the first time, we present findings that similar alterations appear in the lipid profiles of body fluids and tissues in patients. We observe gradual changes in sulfatide and sphingomyelin concentrations with increasing tumor stage andgrade. We built binary classifiers that detect RCC based on plasma and urine lipidome dysregulationsand we show that the plasma lipidome alterations enable distinguishing between early-stage RCC and controls. Our results demonstrate the considerable potential of lipid screening in biofluids for RCC detection and monitoring in clinical settings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA18-12204S" target="_blank" >GA18-12204S: Charakterizace lidského lipidomu a metabolomu pro personalizovanou zdravotní péči a hledání biomarkerů: studie rakoviny ledvin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancers

ISSN

2072-6694

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

18

Strana od-do

4622

Kód UT WoS článku

000866701300001

EID výsledku v databázi Scopus

2-s2.0-85139932391