Effect of timing of reoperation on survival in patients with recurrent glioblastoma: retrospective multicentric descriptive study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73622954" target="_blank" >RIV/61989592:15110/23:73622954 - isvavai.cz</a>

Výsledek na webu

<a href="http://hhttps://www.mdpi.com/2072-6694/15/9/2530" target="_blank" >http://hhttps://www.mdpi.com/2072-6694/15/9/2530</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers15092530" target="_blank" >10.3390/cancers15092530</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of timing of reoperation on survival in patients with recurrent glioblastoma: retrospective multicentric descriptive study

Popis výsledku v původním jazyce

disappearance; (2) The patient&apos;s clinical condition was satisfactory (pcs ≥ 70 % and PS Who ≤ gr. 2); (3) the tumor was located without multifocality; (4) The minimum expected reducing tumor volume was above 80 %. The one -dimensional Cox&apos;s regression analysis of postoperative survival (PSS) revealed a statistically significant influence of reoperation on PSS from Prague 16 months to the first operation. Cox&apos;s regression models that stratified carnof scores with age regulations confirmed a statistically significant improvement in PSS for threshold values of time to progression (TTP) 22 and 24 months. Groups of patients showing the first recurrence in the 22nd and 24th months had better survival than those showing earlier recurrence. In the 22-month age group HR 0.5 s 95% CI (0.27, 0.96) and p-value 0.036. In a 24-month-old group, HR 0.5 s 95% CI (0.25, 0.96) and p-value 0.039 were HR 0.5 s 95% CI (0.25, 0.96). Patients with the longest survival were also the best candidates for repeated surgery. The later glioblastoma recurrence was associated with a higher survival after reoperation.

Název v anglickém jazyce

Effect of timing of reoperation on survival in patients with recurrent glioblastoma: retrospective multicentric descriptive study

Popis výsledku anglicky

disappearance; (2) The patient&apos;s clinical condition was satisfactory (pcs ≥ 70 % and PS Who ≤ gr. 2); (3) the tumor was located without multifocality; (4) The minimum expected reducing tumor volume was above 80 %. The one -dimensional Cox&apos;s regression analysis of postoperative survival (PSS) revealed a statistically significant influence of reoperation on PSS from Prague 16 months to the first operation. Cox&apos;s regression models that stratified carnof scores with age regulations confirmed a statistically significant improvement in PSS for threshold values of time to progression (TTP) 22 and 24 months. Groups of patients showing the first recurrence in the 22nd and 24th months had better survival than those showing earlier recurrence. In the 22-month age group HR 0.5 s 95% CI (0.27, 0.96) and p-value 0.036. In a 24-month-old group, HR 0.5 s 95% CI (0.25, 0.96) and p-value 0.039 were HR 0.5 s 95% CI (0.25, 0.96). Patients with the longest survival were also the best candidates for repeated surgery. The later glioblastoma recurrence was associated with a higher survival after reoperation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancers

ISSN

2072-6694

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

1

Strana od-do

2530

Kód UT WoS článku

000987086900001

EID výsledku v databázi Scopus

2-s2.0-85159559808