Exploring Phthalimide as the Acid Component in the Passerini Reaction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73624805" target="_blank" >RIV/61989592:15110/24:73624805 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/24:73624805

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.orglett.3c03962" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.orglett.3c03962</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.orglett.3c03962" target="_blank" >10.1021/acs.orglett.3c03962</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploring Phthalimide as the Acid Component in the Passerini Reaction

Popis výsledku v původním jazyce

Multicomponent reactions, particularly the Passerini reaction, serve as efficient tools for the synthesis of druglike molecules and the creation of compound libraries. Despite the effectiveness of the Passerini reaction, the limited alternatives to the crucial carboxylic acid component pose a structural constraint. Here, we have discovered that the phthalimide moiety and its derivatives react in the Passerini reaction as an acid component. We explored their potential in synthesizing diverse and intricate molecules. The phthalimide moiety stands out as a favorable building block due to its oxidative stability, heat-stable characteristics, and resistance to solvents. Our approach introduces a novel perspective to multicomponent reactions by incorporating NH-based acid components, addressing the ongoing need for the development of innovative molecular scaffolds.

Název v anglickém jazyce

Exploring Phthalimide as the Acid Component in the Passerini Reaction

Popis výsledku anglicky

Multicomponent reactions, particularly the Passerini reaction, serve as efficient tools for the synthesis of druglike molecules and the creation of compound libraries. Despite the effectiveness of the Passerini reaction, the limited alternatives to the crucial carboxylic acid component pose a structural constraint. Here, we have discovered that the phthalimide moiety and its derivatives react in the Passerini reaction as an acid component. We explored their potential in synthesizing diverse and intricate molecules. The phthalimide moiety stands out as a favorable building block due to its oxidative stability, heat-stable characteristics, and resistance to solvents. Our approach introduces a novel perspective to multicomponent reactions by incorporating NH-based acid components, addressing the ongoing need for the development of innovative molecular scaffolds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ORGANIC LETTERS

ISSN

1523-7060

e-ISSN

1523-7052

Svazek periodika

26

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

829-833

Kód UT WoS článku

001157544400001

EID výsledku v databázi Scopus

2-s2.0-85183486460