Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/ cRGD targeted photodynamic therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73626452" target="_blank" >RIV/61989592:15110/24:73626452 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/24:73626452

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1011134424001702" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1011134424001702</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jphotobiol.2024.113010" target="_blank" >10.1016/j.jphotobiol.2024.113010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/ cRGD targeted photodynamic therapy

Popis výsledku v původním jazyce

Photodynamic therapy (PDT) is a clinically-approved cancer treatment that is based on production of cytotoxic reactive oxygen species to induce cell death. However, its efficiency depends on distribution of photosensitizer (PS) and depth of light penetration through the tissues. Tendency of pathological cancer tissues to exhibit lower pH than healthy tissues inspired us to explore dual-targeted pH-activatable photosensitizers based on tunable near-infrared (NIR) boron-dipyrromethene (BODIPY) dyes. Our BODIPY PSs were designed to carry three main attributes: (i) biotin or cRGD peptide as an effective cancer cell targeting unit, (ii) amino moiety that is protonated in acidic (pH 640nm) allowed for high phototoxicity against HeLa (alpha(v)beta(3) integrin and biotin receptor positive) and A549 (biotin receptor positive) cells compared to healthy MRC-5 (biotin negative) cells. Moreover, no dark toxicity was observed on selected cell lines (&gt;10 mu M) providing promising photosensitizers for tumour-targeted photodynamic therapy.

Název v anglickém jazyce

Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/ cRGD targeted photodynamic therapy

Popis výsledku anglicky

Photodynamic therapy (PDT) is a clinically-approved cancer treatment that is based on production of cytotoxic reactive oxygen species to induce cell death. However, its efficiency depends on distribution of photosensitizer (PS) and depth of light penetration through the tissues. Tendency of pathological cancer tissues to exhibit lower pH than healthy tissues inspired us to explore dual-targeted pH-activatable photosensitizers based on tunable near-infrared (NIR) boron-dipyrromethene (BODIPY) dyes. Our BODIPY PSs were designed to carry three main attributes: (i) biotin or cRGD peptide as an effective cancer cell targeting unit, (ii) amino moiety that is protonated in acidic (pH 640nm) allowed for high phototoxicity against HeLa (alpha(v)beta(3) integrin and biotin receptor positive) and A549 (biotin receptor positive) cells compared to healthy MRC-5 (biotin negative) cells. Moreover, no dark toxicity was observed on selected cell lines (&gt;10 mu M) providing promising photosensitizers for tumour-targeted photodynamic therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/LX22NPO5102" target="_blank" >LX22NPO5102: Národní ústav pro výzkum rakoviny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

ISSN

1011-1344

e-ISSN

1873-2682

Svazek periodika

259

Číslo periodika v rámci svazku

OCT

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

"113010-1"-"113010-10"

Kód UT WoS článku

001296435200001

EID výsledku v databázi Scopus

2-s2.0-85201110348