Added Value in Low-Risk Pregnancies of Longitudinal Changes in Uterine Doppler and Circulating Angiogenic Factors during the Third Trimester in Predicting Term Preeclampsia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73627387" target="_blank" >RIV/61989592:15110/25:73627387 - isvavai.cz</a>

Výsledek na webu

<a href="https://karger.com/fdt/article-abstract/52/3/233/915512/Added-Value-in-Low-Risk-Pregnancies-of?redirectedFrom=fulltext" target="_blank" >https://karger.com/fdt/article-abstract/52/3/233/915512/Added-Value-in-Low-Risk-Pregnancies-of?redirectedFrom=fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000541731" target="_blank" >10.1159/000541731</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Added Value in Low-Risk Pregnancies of Longitudinal Changes in Uterine Doppler and Circulating Angiogenic Factors during the Third Trimester in Predicting Term Preeclampsia

Popis výsledku v původním jazyce

Introduction: The objective of this study was to assess the relationship between longitudinal changes in the uterine Doppler velocimetry and the maternal profile of angiogenic factors in the third trimester and to assess their ability to predict term preeclampsia (PE). Methods: A cohort of low-risk pregnant women was scheduled for a uterine Doppler evaluation and measurement of the circulating levels of angiogenic factors at similar to 30 and similar to 36 weeks. The performance of both parameters and their change over time in predicting term PE was evaluated. Results: A total of 1,191 women were analyzed, of which 28 (2.4%) women developed term PE. At similar to 30 weeks, a model including the sFlt-1/PlGF (fms-like tyrosine kinase-1/placental growth factor) ratio and the uterine Doppler explained 16.2% of the uncertainty of developing term PE, while at similar to 36 weeks, the same variables explained 25.2% [p &lt; 0.001]. The longitudinal changes of both predictors had an R-2 of 26.8%, which was not different from that of the similar to 36 weeks evaluation [p = 0.45]. The area under the curve (AUC) of the similar to 36 weeks ratio was significantly higher than at similar to 30 weeks (0.86 [0.77-0.94] vs. 0.81 [0.73-0.9]; p = 0.043). The AUC of the longitudinal change of the ratio (0.85 [0.77-0.94]) did not differ from that of at similar to 36 weeks (p = 0.82). At similar to 36 weeks, for a 10% of false positives, the ratio had a detection rate of 71.4%. Conclusion: A cross-sectional measurement of the sFlt-1/PlGF ratio outperforms uterine Doppler in predicting term PE. The combination of both markers does not improve such prediction, nor the evaluation of the longitudinal changes between weeks.

Název v anglickém jazyce

Added Value in Low-Risk Pregnancies of Longitudinal Changes in Uterine Doppler and Circulating Angiogenic Factors during the Third Trimester in Predicting Term Preeclampsia

Popis výsledku anglicky

Introduction: The objective of this study was to assess the relationship between longitudinal changes in the uterine Doppler velocimetry and the maternal profile of angiogenic factors in the third trimester and to assess their ability to predict term preeclampsia (PE). Methods: A cohort of low-risk pregnant women was scheduled for a uterine Doppler evaluation and measurement of the circulating levels of angiogenic factors at similar to 30 and similar to 36 weeks. The performance of both parameters and their change over time in predicting term PE was evaluated. Results: A total of 1,191 women were analyzed, of which 28 (2.4%) women developed term PE. At similar to 30 weeks, a model including the sFlt-1/PlGF (fms-like tyrosine kinase-1/placental growth factor) ratio and the uterine Doppler explained 16.2% of the uncertainty of developing term PE, while at similar to 36 weeks, the same variables explained 25.2% [p &lt; 0.001]. The longitudinal changes of both predictors had an R-2 of 26.8%, which was not different from that of the similar to 36 weeks evaluation [p = 0.45]. The area under the curve (AUC) of the similar to 36 weeks ratio was significantly higher than at similar to 30 weeks (0.86 [0.77-0.94] vs. 0.81 [0.73-0.9]; p = 0.043). The AUC of the longitudinal change of the ratio (0.85 [0.77-0.94]) did not differ from that of at similar to 36 weeks (p = 0.82). At similar to 36 weeks, for a 10% of false positives, the ratio had a detection rate of 71.4%. Conclusion: A cross-sectional measurement of the sFlt-1/PlGF ratio outperforms uterine Doppler in predicting term PE. The combination of both markers does not improve such prediction, nor the evaluation of the longitudinal changes between weeks.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FETAL DIAGNOSIS AND THERAPY

ISSN

1015-3837

e-ISSN

1421-9964

Svazek periodika

52

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

233-242

Kód UT WoS článku

001366265800001

EID výsledku v databázi Scopus

2-s2.0-85210909117