Magnetic 2D Transition-Metal-Based Nanomaterials in Biomedicine: Opportunities and Challenges in Cancer Therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73631231" target="_blank" >RIV/61989592:15110/25:73631231 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/25:73631231

Výsledek na webu

<a href="https://www.mdpi.com/1996-1944/18/11/2570" target="_blank" >https://www.mdpi.com/1996-1944/18/11/2570</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ma18112570" target="_blank" >10.3390/ma18112570</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic 2D Transition-Metal-Based Nanomaterials in Biomedicine: Opportunities and Challenges in Cancer Therapy

Popis výsledku v původním jazyce

Severe systemic toxicity and poor targeting efficiency remain major limitations of traditional chemotherapy, emphasising the need for smarter drug delivery systems. Magnetic 2D transition-metal-based nanomaterials offer a promising approach, as they can be designed to combine high drug loading, precise targeting, and controlled release. The key material classes—transition metal dichalcogenides, transition metal carbides/nitrides, transition metal oxides, and metal–organic frameworks—share important physicochemical properties. These include high surface-to-volume ratios, tuneable functionalities, and efficient intracellular uptake. Incorporating magnetic nanoparticles into these 2D structures broadens their potential beyond drug delivery, through enabling multimodal therapeutic strategies such as hyperthermia induction, real-time imaging, and photothermal or photodynamic therapy. This review outlines the potential of magnetic 2D transition-metal-based nanomaterials for biomedical applications by evaluating their therapeutic performance and biological response. In parallel, it offers a critical analysis of how differences in physicochemical properties influence their potential for specific cancer treatment applications, highlighting the most promising uses of each in bionanomedicine.

Název v anglickém jazyce

Magnetic 2D Transition-Metal-Based Nanomaterials in Biomedicine: Opportunities and Challenges in Cancer Therapy

Popis výsledku anglicky

Severe systemic toxicity and poor targeting efficiency remain major limitations of traditional chemotherapy, emphasising the need for smarter drug delivery systems. Magnetic 2D transition-metal-based nanomaterials offer a promising approach, as they can be designed to combine high drug loading, precise targeting, and controlled release. The key material classes—transition metal dichalcogenides, transition metal carbides/nitrides, transition metal oxides, and metal–organic frameworks—share important physicochemical properties. These include high surface-to-volume ratios, tuneable functionalities, and efficient intracellular uptake. Incorporating magnetic nanoparticles into these 2D structures broadens their potential beyond drug delivery, through enabling multimodal therapeutic strategies such as hyperthermia induction, real-time imaging, and photothermal or photodynamic therapy. This review outlines the potential of magnetic 2D transition-metal-based nanomaterials for biomedical applications by evaluating their therapeutic performance and biological response. In parallel, it offers a critical analysis of how differences in physicochemical properties influence their potential for specific cancer treatment applications, highlighting the most promising uses of each in bionanomedicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials

ISSN

1996-1944

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

28

Strana od-do

2570

Kód UT WoS článku

001505978000001

EID výsledku v databázi Scopus

2-s2.0-105007850468