Diffusion-weighted imaging and retinal oximetry as potential biomarkers of visual outcomes after optic neuritis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73632056" target="_blank" >RIV/61989592:15110/25:73632056 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/25:00001548 RIV/00216224:14740/25:00142274 RIV/00098892:_____/25:10159477

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-025-19331-w" target="_blank" >https://www.nature.com/articles/s41598-025-19331-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-19331-w" target="_blank" >10.1038/s41598-025-19331-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diffusion-weighted imaging and retinal oximetry as potential biomarkers of visual outcomes after optic neuritis

Popis výsledku v původním jazyce

To elucidate the mechanisms influencing visual function recovery after optic neuritis (ON), this study employed a multicompartment diffusion weighted imaging (DWI) model to assess the role of optic radiation integrity and its relationship with retinal parameters, including automatic retinal oximetry and retinal nerve fiber layer (RNFL) thinning. Twenty-four patients with the first episode of acute unilateral ON were compared with 56 healthy volunteers with normal vision. Additionally, longitudinal analysis 3 and 6 months after ON was performed in 17 patients. Multivariate analysis of variance across baseline DWI metrics revealed a greater secondary partial volume fraction (f2) in patients. In the longitudinal analysis, a multivariate effect of time was observed only when adjusted for the affected side and time since onset; however, univariate post hoc tests were nonsignificant. An unadjusted model stratified according to clinical outcomes (best-corrected visual acuity [BCVA] and contrast sensitivity) indicated lower overall fractional anisotropy (FA) in patients with incomplete recovery. In the correlation analysis, baseline FA and oximetry (venous saturation and arteriovenous difference) predicted follow-up BCVA, whereas axial diffusivity predicted follow-up oximetry. In turn, baseline oximetry predicted follow-up RNFL thickness. In summary, DWI and retinal oximetry are both potential predictors of visual function outcomes after ON.

Název v anglickém jazyce

Diffusion-weighted imaging and retinal oximetry as potential biomarkers of visual outcomes after optic neuritis

Popis výsledku anglicky

To elucidate the mechanisms influencing visual function recovery after optic neuritis (ON), this study employed a multicompartment diffusion weighted imaging (DWI) model to assess the role of optic radiation integrity and its relationship with retinal parameters, including automatic retinal oximetry and retinal nerve fiber layer (RNFL) thinning. Twenty-four patients with the first episode of acute unilateral ON were compared with 56 healthy volunteers with normal vision. Additionally, longitudinal analysis 3 and 6 months after ON was performed in 17 patients. Multivariate analysis of variance across baseline DWI metrics revealed a greater secondary partial volume fraction (f2) in patients. In the longitudinal analysis, a multivariate effect of time was observed only when adjusted for the affected side and time since onset; however, univariate post hoc tests were nonsignificant. An unadjusted model stratified according to clinical outcomes (best-corrected visual acuity [BCVA] and contrast sensitivity) indicated lower overall fractional anisotropy (FA) in patients with incomplete recovery. In the correlation analysis, baseline FA and oximetry (venous saturation and arteriovenous difference) predicted follow-up BCVA, whereas axial diffusivity predicted follow-up oximetry. In turn, baseline oximetry predicted follow-up RNFL thickness. In summary, DWI and retinal oximetry are both potential predictors of visual function outcomes after ON.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV19-06-00216" target="_blank" >NV19-06-00216: Morfologické a patofyziologické změny sítnice a zrakové dráhy u retrobulbární neuritidy v rámci roztroušené sklerózy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

"Article Number:35445"

Kód UT WoS článku

001591900900036

EID výsledku v databázi Scopus

2-s2.0-105018398817