Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73634128" target="_blank" >RIV/61989592:15110/25:73634128 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1492256/full" target="_blank" >https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1492256/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmed.2025.1492256" target="_blank" >10.3389/fmed.2025.1492256</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression
Popis výsledku v původním jazyce
Chronic obstructive pulmonary disease (COPD) continues to be the world's primary cause of morbidity and mortality. The main mechanism driving the pathogenesis of COPD is oxidative stress. Antioxidant genes, regulated by the Nrf2/ARE signaling pathway, play a protective role against oxidative stress. Unfortunately, this pathway appears to be dysregulated in COPD, leading to decreased expression of antioxidant genes and persistent oxidative stress. We reviewed numerous studies measuring the expression of antioxidant genes in COPD. We also focused on developments in methods used to study gene expression in COPD over time, along with measuring antioxidant gene expression in various cell types, and the potential use of antioxidant gene expression as a predictor of COPD progression. And last but not least we discussed the association of cigarette smoke exposure with antioxidant gene expression together with antioxidant treatment in COPD. Understanding the altered expression of antioxidant genes in COPD could help in treating COPD, as well as predicting its progression.
Název v anglickém jazyce
Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression
Popis výsledku anglicky
Chronic obstructive pulmonary disease (COPD) continues to be the world's primary cause of morbidity and mortality. The main mechanism driving the pathogenesis of COPD is oxidative stress. Antioxidant genes, regulated by the Nrf2/ARE signaling pathway, play a protective role against oxidative stress. Unfortunately, this pathway appears to be dysregulated in COPD, leading to decreased expression of antioxidant genes and persistent oxidative stress. We reviewed numerous studies measuring the expression of antioxidant genes in COPD. We also focused on developments in methods used to study gene expression in COPD over time, along with measuring antioxidant gene expression in various cell types, and the potential use of antioxidant gene expression as a predictor of COPD progression. And last but not least we discussed the association of cigarette smoke exposure with antioxidant gene expression together with antioxidant treatment in COPD. Understanding the altered expression of antioxidant genes in COPD could help in treating COPD, as well as predicting its progression.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30218 - General and internal medicine
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in Medicine
ISSN
2296-858X
e-ISSN
2296-858X
Svazek periodika
12
Číslo periodika v rámci svazku
May
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
10
Strana od-do
1492256
Kód UT WoS článku
001488471500001
EID výsledku v databázi Scopus
2-s2.0-105005269211