Thiazolidinone-based compounds as dual-purpose therapeutics: antimicrobial efficacy, cytotoxicity and pharmacokinetic potential

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73635354" target="_blank" >RIV/61989592:15110/25:73635354 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.uran.ua/sr_pharm/article/view/342467" target="_blank" >https://journals.uran.ua/sr_pharm/article/view/342467</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15587/2519-4852.2025.342467" target="_blank" >10.15587/2519-4852.2025.342467</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thiazolidinone-based compounds as dual-purpose therapeutics: antimicrobial efficacy, cytotoxicity and pharmacokinetic potential

Popis výsledku v původním jazyce

Infectious diseases and cancer remain leading global health challenges, with rising resistance to existing antibiotics and limited selectivity of many cytotoxic agents. Heterocyclic scaffolds, particularly thiazolidinones, offer a promising platform for the development of novel antimicrobial and anticancer compounds. The aim of the study. To evaluate the antimicrobial and cytotoxic properties of thiazolidinone-based compounds against a panel of pathogenic microorganisms and human cancer cell lines, and to identify the most promising derivatives with favorable safety, pharmacokinetic, and mechanistic profiles through molecular docking and dynamics studies. Materials and methods. A library of 5-enamine(hydrazine)-4-thiazolidinone derivatives was screened for antimi-crobial activity against Gram-positive and Gram-negative bacteria and Candida albicans, and for cytotoxic activity against six human cancer cell lines. Minimum inhibitory concentrations (MIC) were determined, and IC50 values were measured for selected compounds. Pharmacokinetic properties, including gastrointestinal absorption and li-pophilicity, were assessed in silico. To investigate potential mechanisms of antibacterial action, molecular docking was performed against MurB

Název v anglickém jazyce

Thiazolidinone-based compounds as dual-purpose therapeutics: antimicrobial efficacy, cytotoxicity and pharmacokinetic potential

Popis výsledku anglicky

Infectious diseases and cancer remain leading global health challenges, with rising resistance to existing antibiotics and limited selectivity of many cytotoxic agents. Heterocyclic scaffolds, particularly thiazolidinones, offer a promising platform for the development of novel antimicrobial and anticancer compounds. The aim of the study. To evaluate the antimicrobial and cytotoxic properties of thiazolidinone-based compounds against a panel of pathogenic microorganisms and human cancer cell lines, and to identify the most promising derivatives with favorable safety, pharmacokinetic, and mechanistic profiles through molecular docking and dynamics studies. Materials and methods. A library of 5-enamine(hydrazine)-4-thiazolidinone derivatives was screened for antimi-crobial activity against Gram-positive and Gram-negative bacteria and Candida albicans, and for cytotoxic activity against six human cancer cell lines. Minimum inhibitory concentrations (MIC) were determined, and IC50 values were measured for selected compounds. Pharmacokinetic properties, including gastrointestinal absorption and li-pophilicity, were assessed in silico. To investigate potential mechanisms of antibacterial action, molecular docking was performed against MurB

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ScienceRise: Pharmaceutical Science

ISSN

2519-4844

e-ISSN

2519-4852

Svazek periodika

5

Číslo periodika v rámci svazku

57

Stát vydavatele periodika

UA - Ukrajina

Počet stran výsledku

14

Strana od-do

88-101

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-105022489828