Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F14%3A33149356" target="_blank" >RIV/61989592:15120/14:33149356 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00702-014-1184-4" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1184-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-014-1184-4" target="_blank" >10.1007/s00702-014-1184-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation

Popis výsledku v původním jazyce

In patients with Wilson's disease (WD) transcranial brain sonography typically reveals areas of increased echogenicity (hyperechogenicity) of the lenticular nucleus (LN). Correlation with T2-hypointensity on magnetic resonance images suggested that LN hyperechogenicity in WD is caused by trace metal accumulation. Accumulation of both, copper and iron, in the brain of WD patients has been reported. The present study was designed to elucidate whether LN hyperechogenicity in WD reflects accumulation of copper or iron. Post-mortem brains of 15 WD patients and one non-WD subject were studied with ultrasonography in an investigator-blinded fashion. LN hyperechogenicity was measured planimetrically by manual tracing as well as using digitized image analysis.The putaminal copper content was determined in samples of 11 WD brains and the non-WD brains using inductively coupled plasma mass spectrometry, and iron content was assessed using flame atomic absorption spectroscopy. LN was normal on ul

Název v anglickém jazyce

Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation

Popis výsledku anglicky

In patients with Wilson's disease (WD) transcranial brain sonography typically reveals areas of increased echogenicity (hyperechogenicity) of the lenticular nucleus (LN). Correlation with T2-hypointensity on magnetic resonance images suggested that LN hyperechogenicity in WD is caused by trace metal accumulation. Accumulation of both, copper and iron, in the brain of WD patients has been reported. The present study was designed to elucidate whether LN hyperechogenicity in WD reflects accumulation of copper or iron. Post-mortem brains of 15 WD patients and one non-WD subject were studied with ultrasonography in an investigator-blinded fashion. LN hyperechogenicity was measured planimetrically by manual tracing as well as using digitized image analysis.The putaminal copper content was determined in samples of 11 WD brains and the non-WD brains using inductively coupled plasma mass spectrometry, and iron content was assessed using flame atomic absorption spectroscopy. LN was normal on ul

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Svazek periodika

2014

Číslo periodika v rámci svazku

121 (10)

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

7

Strana od-do

1273-1279

Kód UT WoS článku

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EID výsledku v databázi Scopus

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