The effects of intradialytic resistance training on muscle strength, psychological well-being, clinical outcomes and circulatory micro-ribonucleic acid profiles in haemodialysis patients Protocol for a quasi-experimental study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15260%2F19%3A73597428" target="_blank" >RIV/61989592:15260/19:73597428 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.lww.com/md-journal/fulltext/2019/05100/The_effects_of_intradialytic_resistance_training.81.aspx" target="_blank" >https://journals.lww.com/md-journal/fulltext/2019/05100/The_effects_of_intradialytic_resistance_training.81.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MD.0000000000015570" target="_blank" >10.1097/MD.0000000000015570</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effects of intradialytic resistance training on muscle strength, psychological well-being, clinical outcomes and circulatory micro-ribonucleic acid profiles in haemodialysis patients Protocol for a quasi-experimental study

Popis výsledku v původním jazyce

Background: Intradialytic resistance training (IRT) protects patients&apos; muscle mass and functions against protein-energy wasting, malnutrition and cachexia. However, the evidence of the effects of such an intervention in haemodialysis patients is limited and not conclusive. To improve the applicability of such interventions, we need a better understanding of molecular, functional and psycho-social adaptation in dialysed patients following a physical training. Therefore, the aim of this study is to investigate the effects of IRT on lower extremity muscle functions, quality of life, and anxiety and depression, clinical outcomes and circulatory micro-ribonucleic acid (miRNA) profiles in patients on chronic haemodialysis therapy. Methods: We will perform a quasi-experimental study in 3 dialysis centres. Patients will be recruited via their nephrologists and will be allocated to an experimental and a control group based on the location of the patients&apos; dialysis centre. Patients allocated to the experimental group will undergo a 12-week IRT, while the control group will remain physically inactive during dialysis. The primary outcome is the change in the maximal force produced during an isometric contraction of lower extremity muscles. Secondary outcomes regard quality of life, anxiety and depression, clinical outcomes and circulatory miRNA profiles. Patients&apos; level of health literacy defined as the ability to get and understand health information will be also measured in the study as a potential modifier of effects. Discussion: This quasi-experimental study can add in an important way to our understanding of the effects of resistance training on dialysis patients&apos; muscle strength, quality of life and disease-specific outcomes.

Název v anglickém jazyce

The effects of intradialytic resistance training on muscle strength, psychological well-being, clinical outcomes and circulatory micro-ribonucleic acid profiles in haemodialysis patients Protocol for a quasi-experimental study

Popis výsledku anglicky

Background: Intradialytic resistance training (IRT) protects patients&apos; muscle mass and functions against protein-energy wasting, malnutrition and cachexia. However, the evidence of the effects of such an intervention in haemodialysis patients is limited and not conclusive. To improve the applicability of such interventions, we need a better understanding of molecular, functional and psycho-social adaptation in dialysed patients following a physical training. Therefore, the aim of this study is to investigate the effects of IRT on lower extremity muscle functions, quality of life, and anxiety and depression, clinical outcomes and circulatory micro-ribonucleic acid (miRNA) profiles in patients on chronic haemodialysis therapy. Methods: We will perform a quasi-experimental study in 3 dialysis centres. Patients will be recruited via their nephrologists and will be allocated to an experimental and a control group based on the location of the patients&apos; dialysis centre. Patients allocated to the experimental group will undergo a 12-week IRT, while the control group will remain physically inactive during dialysis. The primary outcome is the change in the maximal force produced during an isometric contraction of lower extremity muscles. Secondary outcomes regard quality of life, anxiety and depression, clinical outcomes and circulatory miRNA profiles. Patients&apos; level of health literacy defined as the ability to get and understand health information will be also measured in the study as a potential modifier of effects. Discussion: This quasi-experimental study can add in an important way to our understanding of the effects of resistance training on dialysis patients&apos; muscle strength, quality of life and disease-specific outcomes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MEDICINE

ISSN

0025-7974

e-ISSN

—

Svazek periodika

98

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000473112000081

EID výsledku v databázi Scopus

2-s2.0-85066060971