The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F03%3A00001601" target="_blank" >RIV/61989592:15310/03:00001601 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest

Popis výsledku v původním jazyce

The activity of cyclin-dependent kinases (CDK), the key regulators of the cell cycle, is strictly controlled by different mechanisms but is often altered in human cancer. This has stimulated the search for molecules targeting CDK activity as anti-canceragents. Different types of CDK inhibitors have been described, among them, C2-, N6-, N9-substituted purines such as plant cytokinin analogues. We have previously reported the inhibition of CDK1 and CDK2 activity by a new group of plant cytokinin analogu es (Vermeulen et al., Leukemia 2001;16:299). These compounds inhibit proliferation of leukemic cell lines and induce apoptosis, which is initiated by the mitochondrial pathway (Vermeulen et al., Experimen Hemat 2002;30:1107). In this study, the mechanismof CDK inhibitor-induced apoptosis was further characterized. The expression of two Bcl-2 family members (Bcl-2 and Bax) was examined in malignant hematopoietic cell lines after treatment with CDK inhibitors. Bcl-2 prolongs cell survival

Název v anglickém jazyce

The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest

Popis výsledku anglicky

The activity of cyclin-dependent kinases (CDK), the key regulators of the cell cycle, is strictly controlled by different mechanisms but is often altered in human cancer. This has stimulated the search for molecules targeting CDK activity as anti-canceragents. Different types of CDK inhibitors have been described, among them, C2-, N6-, N9-substituted purines such as plant cytokinin analogues. We have previously reported the inhibition of CDK1 and CDK2 activity by a new group of plant cytokinin analogu es (Vermeulen et al., Leukemia 2001;16:299). These compounds inhibit proliferation of leukemic cell lines and induce apoptosis, which is initiated by the mitochondrial pathway (Vermeulen et al., Experimen Hemat 2002;30:1107). In this study, the mechanismof CDK inhibitor-induced apoptosis was further characterized. The expression of two Bcl-2 family members (Bcl-2 and Bax) was examined in malignant hematopoietic cell lines after treatment with CDK inhibitors. Bcl-2 prolongs cell survival

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA301%2F02%2F0475" target="_blank" >GA301/02/0475: Protinádorové a antimitotické látky na bázi purinových inhibitorů cyklin-dependentních kinas</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Experimental Hematology

ISBN

0301-472X

ISSN

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e-ISSN

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Počet stran výsledku

246

Strana od-do

207

Název nakladatele

Elsevier

Místo vydání

New York

Místo konání akce

Paris, France

Datum konání akce

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Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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