Role of DNA repair in antitumor effects of platinum drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00005499" target="_blank" >RIV/61989592:15310/09:00005499 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Role of DNA repair in antitumor effects of platinum drugs

Popis výsledku v původním jazyce

Designing more efficient antitumor platinum-based drugs depends on understanding details of how cells process the existing platinum agents. There is a large body of experimental evidence that the success of platinum complexes in killing tumor cells results from their ability to damage DNA by forming various types of covalent adducts. The adducts formed by platinum antitumor drugs cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to replicate and transcribe the gene that the affected DNA encodes. After DNA is modified by platinum drugs, cellular repair systems recognize this damage. Consequently, the DNA repair process is constantly active as it responds to damage in the DNA structure caused by platinum antitumordrugs. The purpose of this review is to highlight recent discoveries in those pathways triggering tumor cell death that are involved in repairing platinated DNA. The topics discussed in this review do not involve mechanisms underlying rep

Název v anglickém jazyce

Role of DNA repair in antitumor effects of platinum drugs

Popis výsledku anglicky

Designing more efficient antitumor platinum-based drugs depends on understanding details of how cells process the existing platinum agents. There is a large body of experimental evidence that the success of platinum complexes in killing tumor cells results from their ability to damage DNA by forming various types of covalent adducts. The adducts formed by platinum antitumor drugs cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to replicate and transcribe the gene that the affected DNA encodes. After DNA is modified by platinum drugs, cellular repair systems recognize this damage. Consequently, the DNA repair process is constantly active as it responds to damage in the DNA structure caused by platinum antitumordrugs. The purpose of this review is to highlight recent discoveries in those pathways triggering tumor cell death that are involved in repairing platinated DNA. The topics discussed in this review do not involve mechanisms underlying rep

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Metal Complex - DNA Interactions

ISBN

978-1-4051-7629-3

Počet stran výsledku

524

Strana od-do

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Počet stran knihy

544

Název nakladatele

Blackwell

Místo vydání

Oxford

Kód UT WoS kapitoly

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