Nitrace proteinů reaktivními formami dusíku

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010352" target="_blank" >RIV/61989592:15310/09:00010352 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nitrace proteinů reaktivními formami dusíku

Popis výsledku v původním jazyce

This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as wellas by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteinsare observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry.

Název v anglickém jazyce

Nitrace proteinů reaktivními formami dusíku

Popis výsledku anglicky

This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as wellas by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteinsare observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

103

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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