The phytogenic feed additive Sangrovit modulates dextran sulfate sodium-induced colitis in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10212290" target="_blank" >RIV/61989592:15310/10:10212290 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/10:10212290

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The phytogenic feed additive Sangrovit modulates dextran sulfate sodium-induced colitis in rats

Popis výsledku v původním jazyce

Macleaya cordata is an active component of the feed addi?tive Sangrovit. The study was conducted to evaluate the effects of Sangrovit on dextran sulfate sodium (DSS) induced colitis in rats. Rats were assigned to three groups. Group 1 received standard diet and tap water for 14 days, group 2 received 500 ppm Sangrovit in their feed for 14 days and in the second week 5% DSS in the tap water. Group 3 was fed with standard diet, in the second week with 5% DSS in the tap water. The following parameters weremeasured: organ weight, myeloperoxidase activity, expression of cyclooxy?genase-2, hematological parameters, histological analysis and parameters of oxidative stress. The animals from Groups 2 and 3 showed increases in organ weight and changes in the hematological parameters. DSS caused diffuse injury, the Sangrovit group showed less severe damage to the colon mucosa. The Sangrovit diminished expression of DSS induced cyclooxy?genase-2 and mitigated myeloperoxidase activity in colon.

Název v anglickém jazyce

The phytogenic feed additive Sangrovit modulates dextran sulfate sodium-induced colitis in rats

Popis výsledku anglicky

Macleaya cordata is an active component of the feed addi?tive Sangrovit. The study was conducted to evaluate the effects of Sangrovit on dextran sulfate sodium (DSS) induced colitis in rats. Rats were assigned to three groups. Group 1 received standard diet and tap water for 14 days, group 2 received 500 ppm Sangrovit in their feed for 14 days and in the second week 5% DSS in the tap water. Group 3 was fed with standard diet, in the second week with 5% DSS in the tap water. The following parameters weremeasured: organ weight, myeloperoxidase activity, expression of cyclooxy?genase-2, hematological parameters, histological analysis and parameters of oxidative stress. The animals from Groups 2 and 3 showed increases in organ weight and changes in the hematological parameters. DSS caused diffuse injury, the Sangrovit group showed less severe damage to the colon mucosa. The Sangrovit diminished expression of DSS induced cyclooxy?genase-2 and mitigated myeloperoxidase activity in colon.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

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Svazek periodika

55

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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