THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

Kód výsledku v IS VaVaI

RIV/61989592:15310/10:10212887 - isvavai.cz

Nalezeny alternativní kódy

RIV/61989592:15110/10:10212887

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

Popis výsledku v původním jazyce

Silymarin has anti-proliferative and anti-angiogenic activities in-xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased-incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and-selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and-improve the quality of life score (QoL) in men after radical prostatectomy (RP). The selectedcombination of silymarin and selenium significantly reduced two markers of lipid metabolism-known to be associated with PCa progression, LDL and total cholesterol in the blood of men after RP. This-suggests that this combination may be effective in reducing PCa progression.

Název v anglickém jazyce

THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

Popis výsledku anglicky

Silymarin has anti-proliferative and anti-angiogenic activities in-xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased-incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and-selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and-improve the quality of life score (QoL) in men after radical prostatectomy (RP). The selectedcombination of silymarin and selenium significantly reduced two markers of lipid metabolism-known to be associated with PCa progression, LDL and total cholesterol in the blood of men after RP. This-suggests that this combination may be effective in reducing PCa progression.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

2010

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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