Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33118174" target="_blank" >RIV/61989592:15310/11:33118174 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61389030:_____/11:00368601 RIV/60461373:22340/11:43891794 RIV/60461373:22330/11:43891794 RIV/62157124:16370/11:43870800
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.steroids.2011.04.014" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2011.04.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2011.04.014" target="_blank" >10.1016/j.steroids.2011.04.014</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers
Popis výsledku v původním jazyce
Skin penetration enhancers are used in the formulation of transdermal delivery systems for drugs that are otherwise not sufficiently skin-permeable. Intestinal absorption promoters/enhancers are used as excipients in oral formulations of poorly oral-bioavailable drugs. Series of fourteen acyloxy derivatives of 5 beta-cholic acid as potential drug absorption modifiers was generated by multistep synthesis. The synthesis of all newly prepared compounds is presented here. Structure confirmation of all generated compounds was accomplished by (1)H NMR, (13)C NMR, IR and MS spectroscopy methods. All the prepared compounds were analyzed using RP-TLC, and their lipophilicity (R(M)) was determined. The hydrophobicity (log P) and solubility (logS) of the studiedcompounds were also calculated using two commercially available programs.
Název v anglickém jazyce
Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers
Popis výsledku anglicky
Skin penetration enhancers are used in the formulation of transdermal delivery systems for drugs that are otherwise not sufficiently skin-permeable. Intestinal absorption promoters/enhancers are used as excipients in oral formulations of poorly oral-bioavailable drugs. Series of fourteen acyloxy derivatives of 5 beta-cholic acid as potential drug absorption modifiers was generated by multistep synthesis. The synthesis of all newly prepared compounds is presented here. Structure confirmation of all generated compounds was accomplished by (1)H NMR, (13)C NMR, IR and MS spectroscopy methods. All the prepared compounds were analyzed using RP-TLC, and their lipophilicity (R(M)) was determined. The hydrophobicity (log P) and solubility (logS) of the studiedcompounds were also calculated using two commercially available programs.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Steroids
ISSN
0039-128X
e-ISSN
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Svazek periodika
76
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
16
Strana od-do
1082-1097
Kód UT WoS článku
000294074700019
EID výsledku v databázi Scopus
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