Synthesis, X-ray structures, properties and SOD-like activity of ternary copper(II) complexes showing the N4O2 coordination with a combination of monodentate and bidentate N-donor ligands
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33140881" target="_blank" >RIV/61989592:15310/12:33140881 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S0020169311009455" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0020169311009455</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2011.11.021" target="_blank" >10.1016/j.ica.2011.11.021</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Synthesis, X-ray structures, properties and SOD-like activity of ternary copper(II) complexes showing the N4O2 coordination with a combination of monodentate and bidentate N-donor ligands
Popis výsledku v původním jazyce
A series of novel copper(II) complexes with the composition of [Cu(H2O)(2)(L1-5)(2)(phen)].2MeOH (1-5), where HL1 = 6-(2-fluorobenzylamino) purine, HL2 = 6-(3-fluorobenzylamino) purine, HL3 = 6-(4-fluorobenzylamino) purine, HL4 = 6-(2-chlorobenzylamino)purine, HL5 = 6-(3-chlorobenzylamino) purine, phen = 1,10-phenanthroline, was synthesized and characterized by elemental analysis, electronic and infrared spectroscopy, magnetic and conductivity measurements. Single-crystal X-ray analysis of complexes 1-4showed the distorted octahedral geometry in the vicinity of the copper(II) atom, which is coordinated by four nitrogen atoms (two from the bidentate phen ligand and the other two from monodentate 6-(benzylamino) purine derivatives) and two oxygen atomsfrom the aqua ligands, which together form the N4O2 donor set. The antiradical activity of the prepared complexes was tested by an in vitro SOD-like assay. The IC50 values were found ranging between 104 and 146 uM, which represents ca. 0.
Název v anglickém jazyce
Synthesis, X-ray structures, properties and SOD-like activity of ternary copper(II) complexes showing the N4O2 coordination with a combination of monodentate and bidentate N-donor ligands
Popis výsledku anglicky
A series of novel copper(II) complexes with the composition of [Cu(H2O)(2)(L1-5)(2)(phen)].2MeOH (1-5), where HL1 = 6-(2-fluorobenzylamino) purine, HL2 = 6-(3-fluorobenzylamino) purine, HL3 = 6-(4-fluorobenzylamino) purine, HL4 = 6-(2-chlorobenzylamino)purine, HL5 = 6-(3-chlorobenzylamino) purine, phen = 1,10-phenanthroline, was synthesized and characterized by elemental analysis, electronic and infrared spectroscopy, magnetic and conductivity measurements. Single-crystal X-ray analysis of complexes 1-4showed the distorted octahedral geometry in the vicinity of the copper(II) atom, which is coordinated by four nitrogen atoms (two from the bidentate phen ligand and the other two from monodentate 6-(benzylamino) purine derivatives) and two oxygen atomsfrom the aqua ligands, which together form the N4O2 donor set. The antiradical activity of the prepared complexes was tested by an in vitro SOD-like assay. The IC50 values were found ranging between 104 and 146 uM, which represents ca. 0.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CA - Anorganická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Inorganica Chimica Acta
ISSN
0020-1693
e-ISSN
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Svazek periodika
384
Číslo periodika v rámci svazku
APR
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
47-53
Kód UT WoS článku
000301179600007
EID výsledku v databázi Scopus
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