Practical Aspects of Combinatorial Solid-Phase Synthesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33141482" target="_blank" >RIV/61989592:15310/12:33141482 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Practical Aspects of Combinatorial Solid-Phase Synthesis

Popis výsledku v původním jazyce

Combinatorial chemistry is a powerful and efficient technology that has already become an integral part of discovery processes, including drug discovery. In contrast to the traditional medicinal chemistry approach characterized by evaluating the effect of one structural modification at a time, the fundamental aspect of the combinatorial approach resides in the opportunity to evaluate the effect of a combination of individual structural and functional modifications in a molecule. As a result of the combinatorial method of constructing compounds, the number of synthesized compounds exceeds the traditional approach by several orders of magnitude and provides chemical libraries. Hence, the logistics and instrumentation for combinatorial synthesis are an important issue. In this contribution, we will discuss the logistics and practical aspects of combinatorial solid-phase synthesis.

Název v anglickém jazyce

Practical Aspects of Combinatorial Solid-Phase Synthesis

Popis výsledku anglicky

Combinatorial chemistry is a powerful and efficient technology that has already become an integral part of discovery processes, including drug discovery. In contrast to the traditional medicinal chemistry approach characterized by evaluating the effect of one structural modification at a time, the fundamental aspect of the combinatorial approach resides in the opportunity to evaluate the effect of a combination of individual structural and functional modifications in a molecule. As a result of the combinatorial method of constructing compounds, the number of synthesized compounds exceeds the traditional approach by several orders of magnitude and provides chemical libraries. Hence, the logistics and instrumentation for combinatorial synthesis are an important issue. In this contribution, we will discuss the logistics and practical aspects of combinatorial solid-phase synthesis.

Druh

C - Kapitola v odborné knize

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Solid-Phase Organic Synthesis: Concepts, Strategies and Applications

ISBN

978-0-470-59914-3

Počet stran výsledku

36

Strana od-do

95-130

Počet stran knihy

536

Název nakladatele

John Wiley

Místo vydání

New Jersey

Kód UT WoS kapitoly

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