Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33146181" target="_blank" >RIV/61989592:15310/13:33146181 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/13:33146181

Výsledek na webu

<a href="http://adc.mef.hr/index.php/adc/article/view/1008" target="_blank" >http://adc.mef.hr/index.php/adc/article/view/1008</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds

Popis výsledku v původním jazyce

Levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alfa (TNF-alfa) may influence wound healing and wound closure in non-healing wounds. The aim of the study was to test the hypothesis that hydrogencalcium salts of oxidized cellulose change the production of matrix metalloproteinases (MMPs) and TNF-alfa, wound size and number of bacterial strains in non-healing wounds. We analyzed MMP-2, MMP-9 and TNF-alfa in the wound fluid from 20 patients by ELISA every fourteen days over six weeks. Wound size, pain, wound closure and bacterial strains in the wound were also investigated. The wound size was reduced in 14 patients and pain in 16 patients. Bacterial contamination of the wound decreased significantly after treatment. The level of MMP-2 correlated with TNF-alfa production. The level of MMP-9 was unchanged during the healing period. We conclude that hydrogencalcium salts of oxidized cellulose have a favorable effect on the reduction

Název v anglickém jazyce

Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-alfa Production and Wound Healing in Non-Healing Wounds

Popis výsledku anglicky

Levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alfa (TNF-alfa) may influence wound healing and wound closure in non-healing wounds. The aim of the study was to test the hypothesis that hydrogencalcium salts of oxidized cellulose change the production of matrix metalloproteinases (MMPs) and TNF-alfa, wound size and number of bacterial strains in non-healing wounds. We analyzed MMP-2, MMP-9 and TNF-alfa in the wound fluid from 20 patients by ELISA every fourteen days over six weeks. Wound size, pain, wound closure and bacterial strains in the wound were also investigated. The wound size was reduced in 14 patients and pain in 16 patients. Bacterial contamination of the wound decreased significantly after treatment. The level of MMP-2 correlated with TNF-alfa production. The level of MMP-9 was unchanged during the healing period. We conclude that hydrogencalcium salts of oxidized cellulose have a favorable effect on the reduction

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Dermatovenerologica Croatica

ISSN

1330-027X

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

5

Strana od-do

219-223

Kód UT WoS článku

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EID výsledku v databázi Scopus

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