Amides derived from heteroaromatic amines and selected steryl hemiesters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147873" target="_blank" >RIV/61989592:15310/13:33147873 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/13:00398419 RIV/61388963:_____/13:00398419 RIV/61989592:15110/13:33147873 RIV/60461373:22330/13:43895382

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0039128X13002171" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X13002171</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.steroids.2013.10.003" target="_blank" >10.1016/j.steroids.2013.10.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Amides derived from heteroaromatic amines and selected steryl hemiesters

Popis výsledku v původním jazyce

The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 m

Název v anglickém jazyce

Amides derived from heteroaromatic amines and selected steryl hemiesters

Popis výsledku anglicky

The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 m

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Steroids

ISSN

0039-128X

e-ISSN

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Svazek periodika

78

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1347-1352

Kód UT WoS článku

000328303300006

EID výsledku v databázi Scopus

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