Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151900" target="_blank" >RIV/61989592:15310/14:33151900 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/14:33151900

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0040403914007588" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0040403914007588</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tetlet.2014.04.121" target="_blank" >10.1016/j.tetlet.2014.04.121</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones

Popis výsledku v původním jazyce

The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives.

Název v anglickém jazyce

Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones

Popis výsledku anglicky

The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tetrahedron Letters

ISSN

0040-4039

e-ISSN

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Svazek periodika

55

Číslo periodika v rámci svazku

26

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

3592-3595

Kód UT WoS článku

000337868300004

EID výsledku v databázi Scopus

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