Biologically Active Triterpenoids Usable As Prodrugs

Kód výsledku v IS VaVaI

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RIV/61389030:_____/15:00447783 RIV/61989592:15110/15:33152706

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Biologically Active Triterpenoids Usable As Prodrugs

Popis výsledku v původním jazyce

Triterpenoids are a large group of natural compounds, many of which have interesting biological activities. Despite this, only a few derivatives are currently used as therapeutics. The main reason is that the active triterpenes usually have unfavorable pharmacological and physicochemical properties such as solubility and bioavailability. Therefore, many compounds with excellent activity in in vitro tests usually fail during clinical trial. Many research groups have tried to synthesize a variety of prodrugs in order to improve pharmacological properties of the active compound while retaining the desired biological activity. The most commonly chosen functional groups in triterpenes to be modified as prodrugs are hydroxyl and carboxyl. In this chapter, weare going to summarize all of the research that has been done in the area of triterpenoid prodrugs with the main focus on the modifications of hydroxyls and carboxyls. Commonly used types of prodrug groups (such as simple alkyl esters, o

Název v anglickém jazyce

Biologically Active Triterpenoids Usable As Prodrugs

Popis výsledku anglicky

Triterpenoids are a large group of natural compounds, many of which have interesting biological activities. Despite this, only a few derivatives are currently used as therapeutics. The main reason is that the active triterpenes usually have unfavorable pharmacological and physicochemical properties such as solubility and bioavailability. Therefore, many compounds with excellent activity in in vitro tests usually fail during clinical trial. Many research groups have tried to synthesize a variety of prodrugs in order to improve pharmacological properties of the active compound while retaining the desired biological activity. The most commonly chosen functional groups in triterpenes to be modified as prodrugs are hydroxyl and carboxyl. In this chapter, weare going to summarize all of the research that has been done in the area of triterpenoid prodrugs with the main focus on the modifications of hydroxyls and carboxyls. Commonly used types of prodrug groups (such as simple alkyl esters, o

Druh

C - Kapitola v odborné knize

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Terpenoids and Squalene: Biosynthesis, Functions and Health Implications

ISBN

978-1-63463-656-8

Počet stran výsledku

25

Strana od-do

25-49

Počet stran knihy

90

Název nakladatele

Nova Science Publisher, Inc.

Místo vydání

USA

Kód UT WoS kapitoly

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