ATM gene single nucleotide polymorphisms predict regimen-related gastrointestinal toxicity in patients allografted after reduced conditioning

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33154346" target="_blank" >RIV/61989592:15310/15:33154346 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/15:33154346

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1083879115001512" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1083879115001512</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbmt.2015.02.021" target="_blank" >10.1016/j.bbmt.2015.02.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

ATM gene single nucleotide polymorphisms predict regimen-related gastrointestinal toxicity in patients allografted after reduced conditioning

Popis výsledku v původním jazyce

Polymorphisms of genes involved in innate and adaptive immunity have become an object of major interest in regard to hematopoietic stem cell transplantation (HSCT) complications. Regimen-related gastrointestinal toxicity (RR-GIT) is the dominant complication during the pre-engraftment period and has been linked to increased risk of Graft-versus-Host disease (GvHD) development. According to our hypothesis functional variants of genes participating in DNA-damage response (DDR) may have an impact on the extent of tissue damage caused by the conditioning regimen. In our single-center study we analyzed 62 patients who underwent HSCT from HLA-identical donors after reduced-conditionings. The patients were genotyped for five single nucleotide polymorphisms (SNPs, rs4585 T/G, rs189037 A/G, rs227092 T/G, rs228590 C/T, and rs664677 T/C) of the ATM gene - the essential member of the DDR pathways, using allele-specific MALDI-TOF mass spectrometry assay. Because of almost absolute linkage disequili

Název v anglickém jazyce

ATM gene single nucleotide polymorphisms predict regimen-related gastrointestinal toxicity in patients allografted after reduced conditioning

Popis výsledku anglicky

Polymorphisms of genes involved in innate and adaptive immunity have become an object of major interest in regard to hematopoietic stem cell transplantation (HSCT) complications. Regimen-related gastrointestinal toxicity (RR-GIT) is the dominant complication during the pre-engraftment period and has been linked to increased risk of Graft-versus-Host disease (GvHD) development. According to our hypothesis functional variants of genes participating in DNA-damage response (DDR) may have an impact on the extent of tissue damage caused by the conditioning regimen. In our single-center study we analyzed 62 patients who underwent HSCT from HLA-identical donors after reduced-conditionings. The patients were genotyped for five single nucleotide polymorphisms (SNPs, rs4585 T/G, rs189037 A/G, rs227092 T/G, rs228590 C/T, and rs664677 T/C) of the ATM gene - the essential member of the DDR pathways, using allele-specific MALDI-TOF mass spectrometry assay. Because of almost absolute linkage disequili

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12454" target="_blank" >NT12454: Vybrané imunologické a imunogenetické parametry v predikci nemoci štěpu proti hostiteli (GVHD) a úspěšnosti alogenní transplantace krvetvorných kmenových buněk</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biology of Blood and Marrow Transplantation

ISSN

1083-8791

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1136-1140

Kód UT WoS článku

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EID výsledku v databázi Scopus

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