The non-innocent nature of graphene oxide as a theranostic platform for biomedical applications and its reactivity towards metal-based anticancer drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33155615" target="_blank" >RIV/61989592:15310/15:33155615 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra13831k" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra13831k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c5ra13831k" target="_blank" >10.1039/c5ra13831k</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The non-innocent nature of graphene oxide as a theranostic platform for biomedical applications and its reactivity towards metal-based anticancer drugs

Popis výsledku v původním jazyce

The self-assembly process in a solution of a mononuclear iron(II) complex based on the bispyrazolylpyridine scaffold with graphene oxide (GO) micrometer-sheets allows not only the devising of a new hybrid-architecture for GO-based materials suitable fornanomedicine, but also the unveiling of the reactive nature of GO as a drug-carrier. The neat iron complex is found to be highly active in disrupting the cell cycle through DNA binding, with behaviour and efficiency similar to that expressed by ruthenium-complexes as well as antibiotic-drugs such as doxorubicin. On the contrary, in the hybrid material the proclivity of neat GO to produce reactive oxygen species (ROS) became down-regulated by the electron-buffering properties of the loaded iron complex,evidencing the presence of an active electron transfer from the drug to GO. These findings question the use of the neat GO platform as a suitable carrier for metal-based anticancer drugs and highlight the importance of addressing the chem

Název v anglickém jazyce

The non-innocent nature of graphene oxide as a theranostic platform for biomedical applications and its reactivity towards metal-based anticancer drugs

Popis výsledku anglicky

The self-assembly process in a solution of a mononuclear iron(II) complex based on the bispyrazolylpyridine scaffold with graphene oxide (GO) micrometer-sheets allows not only the devising of a new hybrid-architecture for GO-based materials suitable fornanomedicine, but also the unveiling of the reactive nature of GO as a drug-carrier. The neat iron complex is found to be highly active in disrupting the cell cycle through DNA binding, with behaviour and efficiency similar to that expressed by ruthenium-complexes as well as antibiotic-drugs such as doxorubicin. On the contrary, in the hybrid material the proclivity of neat GO to produce reactive oxygen species (ROS) became down-regulated by the electron-buffering properties of the loaded iron complex,evidencing the presence of an active electron transfer from the drug to GO. These findings question the use of the neat GO platform as a suitable carrier for metal-based anticancer drugs and highlight the importance of addressing the chem

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances (online)

ISSN

2046-2069

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

93

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

76556-76566

Kód UT WoS článku

000361387300088

EID výsledku v databázi Scopus

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