Hsp70 as an indicator of stress in the cells after contact with nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156628" target="_blank" >RIV/61989592:15310/15:33156628 - isvavai.cz</a>

Výsledek na webu

<a href="http://iopscience.iop.org/article/10.1088/1742-6596/617/1/012023/pdf" target="_blank" >http://iopscience.iop.org/article/10.1088/1742-6596/617/1/012023/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1742-6596/617/1/012023" target="_blank" >10.1088/1742-6596/617/1/012023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hsp70 as an indicator of stress in the cells after contact with nanoparticles

Popis výsledku v původním jazyce

Heat shock proteins (HSP) are among the substances that can be used for monitoring stress in cells. HSP are structures with a chaperone activity. They are evolutionarily very old, conservative and they are found with a high degree of homology in prokaryotes and eukaryotes including humans. They exist at low concentrations under physiological conditions, while in the denaturing conditions e.g. high or low temperature, radiation, exposure to chemicals, heavy metals, or nanoparticles their expression is changed. HSPs are involved in maintaining homeostasis in the cell that the denatured protein conformations allow recovery to the original stage. One of the most common proteins from HSP family is Hsp70 - protein with a molecular weight of 70 kDa. The levelof Hsp70 in a cell after exposure to the stress changes depending on the stress level to which the cell is exposed to and a time period during which lasted stressful conditions. Our research monitors stress levels of cells manifesting by

Název v anglickém jazyce

Hsp70 as an indicator of stress in the cells after contact with nanoparticles

Popis výsledku anglicky

Heat shock proteins (HSP) are among the substances that can be used for monitoring stress in cells. HSP are structures with a chaperone activity. They are evolutionarily very old, conservative and they are found with a high degree of homology in prokaryotes and eukaryotes including humans. They exist at low concentrations under physiological conditions, while in the denaturing conditions e.g. high or low temperature, radiation, exposure to chemicals, heavy metals, or nanoparticles their expression is changed. HSPs are involved in maintaining homeostasis in the cell that the denatured protein conformations allow recovery to the original stage. One of the most common proteins from HSP family is Hsp70 - protein with a molecular weight of 70 kDa. The levelof Hsp70 in a cell after exposure to the stress changes depending on the stress level to which the cell is exposed to and a time period during which lasted stressful conditions. Our research monitors stress levels of cells manifesting by

Druh

D - Stať ve sborníku

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Journal of Physics Conference Series

ISBN

—

ISSN

1742-6588

e-ISSN

—

Počet stran výsledku

8

Strana od-do

"012023-1"-"012023-8"

Název nakladatele

Institute of Physics

Místo vydání

Bristol

Místo konání akce

Grenoble

Datum konání akce

18. 11. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000358033300023