Synthesis and biological activity evaluation of Schiff bases of 5-acyl-1,2,4-triazine

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156948" target="_blank" >RIV/61989592:15310/15:33156948 - isvavai.cz</a>
Výsledek na webu
<a href="http://jcsp.org.pk/PublishedVersion/4163c0ab-d5d9-4503-bf16-9fd496a6271dManuscript%20no%2014,%20Final%20Gally%20Proof%20of%2010139%20(Mariusz%20Mojzych).pdf" target="_blank" >http://jcsp.org.pk/PublishedVersion/4163c0ab-d5d9-4503-bf16-9fd496a6271dManuscript%20no%2014,%20Final%20Gally%20Proof%20of%2010139%20(Mariusz%20Mojzych).pdf</a>
DOI - Digital Object Identifier
—

Jazyk výsledku
angličtina
Název v původním jazyce
Synthesis and biological activity evaluation of Schiff bases of 5-acyl-1,2,4-triazine
Popis výsledku v původním jazyce
A simple and general method has been developed for the synthesis of various Schiff bases (oximes, hydrazones, semicarbazones and thiosemicarbazones) derived from 5-acyl-1,2,4-triazines. Some of the new synthesized Schiff bases were tested for biologicalactivity but only oximes 2a-c shown poor antiviral activity. The oxime derivatives of 5-acyl-3-methylsulfanyl-1,2,4-triazine were tested with pea-seedling diamine oxidase as the enzyme is known to be inhibited by oxime compounds. However, only weak non-competitive inhibitory effects were observed (Ki of 10-2 M).
Název v anglickém jazyce
Synthesis and biological activity evaluation of Schiff bases of 5-acyl-1,2,4-triazine
Popis výsledku anglicky
A simple and general method has been developed for the synthesis of various Schiff bases (oximes, hydrazones, semicarbazones and thiosemicarbazones) derived from 5-acyl-1,2,4-triazines. Some of the new synthesized Schiff bases were tested for biologicalactivity but only oximes 2a-c shown poor antiviral activity. The oxime derivatives of 5-acyl-3-methylsulfanyl-1,2,4-triazine were tested with pea-seedling diamine oxidase as the enzyme is known to be inhibited by oxime compounds. However, only weak non-competitive inhibitory effects were observed (Ki of 10-2 M).

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
—

Projekt
<a href="/cs/project/GA522%2F08%2F0555" target="_blank" >GA522/08/0555: Strukturně-funkční charakterizace oxidoreduktas působících na dusíkaté regulační látky v rostlinách</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Podobné výsledky(10)